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Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-144 Sentence denotes A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells.
T1 0-144 Sentence denotes A metabolic labeling approach for glycoproteomic analysis reveals altered glycoprotein expression upon GALNT3 knockdown in ovarian cancer cells.
TextSentencer_T2 145-156 Sentence denotes UNLABELLED:
T2 145-156 Sentence denotes UNLABELLED:
TextSentencer_T3 157-303 Sentence denotes Epithelial ovarian cancer (EOC) is a disease responsible for more deaths among women in the Western world than all other gynecologic malignancies.
T3 157-303 Sentence denotes Epithelial ovarian cancer (EOC) is a disease responsible for more deaths among women in the Western world than all other gynecologic malignancies.
TextSentencer_T4 304-414 Sentence denotes There is urgent need for new therapeutic targets and a better understanding of EOC initiation and progression.
T4 304-414 Sentence denotes There is urgent need for new therapeutic targets and a better understanding of EOC initiation and progression.
TextSentencer_T5 415-716 Sentence denotes We have previously identified the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) gene, a member of the GalNAc-transferases (GalNAc-Ts) gene family, as hypomethylated and overexpressed in high-grade serous EOC tumors, compared to low malignant potential EOC tumors and normal ovarian tissues.
T5 415-716 Sentence denotes We have previously identified the polypeptide N-acetylgalactosaminyltransferase 3 (GALNT3) gene, a member of the GalNAc-transferases (GalNAc-Ts) gene family, as hypomethylated and overexpressed in high-grade serous EOC tumors, compared to low malignant potential EOC tumors and normal ovarian tissues.
TextSentencer_T6 717-837 Sentence denotes This data also suggested for a role of GALNT3 in aberrant EOC glycosylation, possibly implicated in disease progression.
T6 717-837 Sentence denotes This data also suggested for a role of GALNT3 in aberrant EOC glycosylation, possibly implicated in disease progression.
TextSentencer_T7 838-1100 Sentence denotes To evaluate differential glycosylation in EOC caused by modulations in GALNT3 expression, we used a metabolic labeling strategy for enrichment and mass spectrometry-based characterization of glycoproteins following GALNT3 gene knockdown (KD) in A2780s EOC cells.
T7 838-1100 Sentence denotes To evaluate differential glycosylation in EOC caused by modulations in GALNT3 expression, we used a metabolic labeling strategy for enrichment and mass spectrometry-based characterization of glycoproteins following GALNT3 gene knockdown (KD) in A2780s EOC cells.
TextSentencer_T8 1101-1186 Sentence denotes A total of 589 differentially expressed glycoproteins were identified upon GALNT3 KD.
T8 1101-1186 Sentence denotes A total of 589 differentially expressed glycoproteins were identified upon GALNT3 KD.
TextSentencer_T9 1187-1368 Sentence denotes Most identified proteins were involved in mechanisms of cellular metabolic functions, post-translational modifications, and some have been reported to be implicated in EOC etiology.
T9 1187-1368 Sentence denotes Most identified proteins were involved in mechanisms of cellular metabolic functions, post-translational modifications, and some have been reported to be implicated in EOC etiology.
TextSentencer_T10 1369-1579 Sentence denotes The GALNT3-dependent glycoproteins identified by this metabolic labeling approach support the oncogenic role of GALNT3 in EOC dissemination and may be pursued as novel EOC biomarkers and/or therapeutic targets.
T10 1369-1579 Sentence denotes The GALNT3-dependent glycoproteins identified by this metabolic labeling approach support the oncogenic role of GALNT3 in EOC dissemination and may be pursued as novel EOC biomarkers and/or therapeutic targets.
TextSentencer_T11 1580-1604 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T11 1580-1604 Sentence denotes BIOLOGICAL SIGNIFICANCE:
TextSentencer_T12 1605-1756 Sentence denotes Knowledge of the O-glycoproteome has been relatively elusive, and the functions of the individual polypeptide GalNAc-Ts have been poorly characterized.
T12 1605-1756 Sentence denotes Knowledge of the O-glycoproteome has been relatively elusive, and the functions of the individual polypeptide GalNAc-Ts have been poorly characterized.
TextSentencer_T13 1757-1896 Sentence denotes Alterations in GalNAc-Ts expression were shown to provide huge variability in the O-glycoproteome in various pathologies, including cancer.
T13 1757-1896 Sentence denotes Alterations in GalNAc-Ts expression were shown to provide huge variability in the O-glycoproteome in various pathologies, including cancer.
TextSentencer_T14 1897-2149 Sentence denotes The application of a chemical biology approach for the metabolic labeling and subsequent characterization of O-glycoproteins in EOC using the Ac4GalNAz metabolite has provided a strategy allowing for proteomic discovery of GalNAc-Ts specific functions.
T14 1897-2149 Sentence denotes The application of a chemical biology approach for the metabolic labeling and subsequent characterization of O-glycoproteins in EOC using the Ac4GalNAz metabolite has provided a strategy allowing for proteomic discovery of GalNAc-Ts specific functions.
TextSentencer_T15 2150-2307 Sentence denotes Our study supports an essential role of one of the GalNAc-Ts - GALNT3, in EOC dissemination, including its implication in modulating PTMs and EOC metabolism.
T15 2150-2307 Sentence denotes Our study supports an essential role of one of the GalNAc-Ts - GALNT3, in EOC dissemination, including its implication in modulating PTMs and EOC metabolism.
TextSentencer_T16 2308-2456 Sentence denotes Our approach validates the use of the applied metabolic strategy to identify important functions of GalNAc-Ts in normal and pathological conditions.
T16 2308-2456 Sentence denotes Our approach validates the use of the applied metabolic strategy to identify important functions of GalNAc-Ts in normal and pathological conditions.