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PubMed:26949059 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-82 Sentence denotes Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer.
T1 0-82 Sentence denotes Tumor-suppressive functions of long-chain acyl-CoA synthetase 4 in gastric cancer.
TextSentencer_T2 83-214 Sentence denotes Long chain acyl CoA synthetase 4 (ACSL4) is a key enzyme in fatty acid metabolism with marked preference for arachidonic acid (AA).
T2 83-214 Sentence denotes Long chain acyl CoA synthetase 4 (ACSL4) is a key enzyme in fatty acid metabolism with marked preference for arachidonic acid (AA).
TextSentencer_T3 215-281 Sentence denotes Recent reports have implicated its crucial roles in tumorigenesis.
T3 215-281 Sentence denotes Recent reports have implicated its crucial roles in tumorigenesis.
TextSentencer_T4 282-366 Sentence denotes However in gastric cancer (GC), the expression and function of ACSL4 remain unclear.
T4 282-366 Sentence denotes However in gastric cancer (GC), the expression and function of ACSL4 remain unclear.
TextSentencer_T5 367-447 Sentence denotes In the present study, we identified ACSL4 as a potential tumor suppressor in GC.
T5 367-447 Sentence denotes In the present study, we identified ACSL4 as a potential tumor suppressor in GC.
TextSentencer_T6 448-539 Sentence denotes The ACSL4 expression in GC samples was evaluated by real-time PCR and immunohistochemistry.
T6 448-539 Sentence denotes The ACSL4 expression in GC samples was evaluated by real-time PCR and immunohistochemistry.
TextSentencer_T7 540-716 Sentence denotes The results indicated that the mRNA and protein levels of ACSL4 were frequently downregulated in cancer tissues compared with the adjacent non-cancerous mucosa control tissues.
T7 540-716 Sentence denotes The results indicated that the mRNA and protein levels of ACSL4 were frequently downregulated in cancer tissues compared with the adjacent non-cancerous mucosa control tissues.
TextSentencer_T8 717-895 Sentence denotes Cell-based functional assays exhibited that ectopic expression of ACSL4 inhibits cell growth, colony formation and cell migration, whereas ACSL4 knockdown enhanced these effects.
T8 717-895 Sentence denotes Cell-based functional assays exhibited that ectopic expression of ACSL4 inhibits cell growth, colony formation and cell migration, whereas ACSL4 knockdown enhanced these effects.
TextSentencer_T9 896-988 Sentence denotes In a nude mice model, ACSL4 knockdown also promoted subcutaneous xenografts' growth in vivo.
T9 896-988 Sentence denotes In a nude mice model, ACSL4 knockdown also promoted subcutaneous xenografts' growth in vivo.
TextSentencer_T10 989-1106 Sentence denotes Moreover, western blot analysis revealed that ACSL4 expression had a significant effect on FAK and P21 protein level.
T10 989-1106 Sentence denotes Moreover, western blot analysis revealed that ACSL4 expression had a significant effect on FAK and P21 protein level.
TextSentencer_T11 1107-1222 Sentence denotes These findings suggest that ACSL4 plays a tumor-suppressive role and could be a potential therapeutic target in GC.
T11 1107-1222 Sentence denotes These findings suggest that ACSL4 plays a tumor-suppressive role and could be a potential therapeutic target in GC.