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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-58 Sentence denotes The role of inflammation in the pathology of preeclampsia.
T1 0-58 Sentence denotes The role of inflammation in the pathology of preeclampsia.
TextSentencer_T2 59-190 Sentence denotes Preeclampsia (PE) affects 5-7% of all pregnancies in the United States and is the leading cause of maternal and prenatal morbidity.
T2 59-190 Sentence denotes Preeclampsia (PE) affects 5-7% of all pregnancies in the United States and is the leading cause of maternal and prenatal morbidity.
TextSentencer_T3 191-316 Sentence denotes PE is associated with hypertension after week 20 of gestation, decreased renal function and small-for-gestational-age babies.
T3 191-316 Sentence denotes PE is associated with hypertension after week 20 of gestation, decreased renal function and small-for-gestational-age babies.
TextSentencer_T4 317-393 Sentence denotes Women with PE exhibit chronic inflammation and production of autoantibodies.
T4 317-393 Sentence denotes Women with PE exhibit chronic inflammation and production of autoantibodies.
TextSentencer_T5 394-642 Sentence denotes It is hypothesized that during PE, placental ischaemia occurs as a result of shallow trophoblast invasion which is associated with an immune imbalance where pro-inflammatory CD4(+) T-cells are increased and T regulatory cells (Tregs) are decreased.
T5 394-642 Sentence denotes It is hypothesized that during PE, placental ischaemia occurs as a result of shallow trophoblast invasion which is associated with an immune imbalance where pro-inflammatory CD4(+) T-cells are increased and T regulatory cells (Tregs) are decreased.
TextSentencer_T6 643-769 Sentence denotes This imbalance leads to chronic inflammation characterized by oxidative stress, pro-inflammatory cytokines and autoantibodies.
T6 643-769 Sentence denotes This imbalance leads to chronic inflammation characterized by oxidative stress, pro-inflammatory cytokines and autoantibodies.
TextSentencer_T7 770-940 Sentence denotes Studies conducted in our laboratory have demonstrated the importance of this immune imbalance in causing hypertension in response to placental ischaemia in pregnant rats.
T7 770-940 Sentence denotes Studies conducted in our laboratory have demonstrated the importance of this immune imbalance in causing hypertension in response to placental ischaemia in pregnant rats.
TextSentencer_T8 941-1207 Sentence denotes These studies confirm that increased CD4(+) T-cells and decreased Tregs during pregnancy leads to elevated inflammatory cytokines, endothelin (ET-1), reactive oxygen species (ROS) and agonistic autoantibodies to the angiotensin II (Ang II), type 1 receptor (AT1-AA).
T8 941-1207 Sentence denotes These studies confirm that increased CD4(+) T-cells and decreased Tregs during pregnancy leads to elevated inflammatory cytokines, endothelin (ET-1), reactive oxygen species (ROS) and agonistic autoantibodies to the angiotensin II (Ang II), type 1 receptor (AT1-AA).
TextSentencer_T9 1208-1317 Sentence denotes All of these factors taken together play an important role in increasing the blood pressure during pregnancy.
T9 1208-1317 Sentence denotes All of these factors taken together play an important role in increasing the blood pressure during pregnancy.
TextSentencer_T10 1318-1506 Sentence denotes Specifically, this review focuses on the decrease in Tregs, and their associated regulatory cytokine interleukin (IL)-10, which is seen in response to placental ischaemia during pregnancy.
T10 1318-1506 Sentence denotes Specifically, this review focuses on the decrease in Tregs, and their associated regulatory cytokine interleukin (IL)-10, which is seen in response to placental ischaemia during pregnancy.
TextSentencer_T11 1507-1615 Sentence denotes This study will also examine the effect of regulatory immune cell repopulation on the pathophysiology of PE.
T11 1507-1615 Sentence denotes This study will also examine the effect of regulatory immune cell repopulation on the pathophysiology of PE.
TextSentencer_T12 1616-1859 Sentence denotes These studies show that restoring the balance of the immune system through increasing Tregs, either by adoptive transfer or by infusing IL-10, reduces the blood pressure and pathophysiology associated with placental ischaemia in pregnant rats.
T12 1616-1859 Sentence denotes These studies show that restoring the balance of the immune system through increasing Tregs, either by adoptive transfer or by infusing IL-10, reduces the blood pressure and pathophysiology associated with placental ischaemia in pregnant rats.