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PubMed:26844271 JSONTXT 6 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-138 Sentence denotes The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells.
T1 0-138 Sentence denotes The Mechanism by Which MYCN Amplification Confers an Enhanced Sensitivity to a PCNA-Derived Cell Permeable Peptide in Neuroblastoma Cells.
TextSentencer_T2 139-218 Sentence denotes Dysregulated expression of MYC family genes is a hallmark of many malignancies.
T2 139-218 Sentence denotes Dysregulated expression of MYC family genes is a hallmark of many malignancies.
TextSentencer_T3 219-333 Sentence denotes Unfortunately, these proteins are not amenable to blockade by small molecules or protein-based therapeutic agents.
T3 219-333 Sentence denotes Unfortunately, these proteins are not amenable to blockade by small molecules or protein-based therapeutic agents.
TextSentencer_T4 334-410 Sentence denotes Therefore, we must find alternative approaches to target MYC-driven cancers.
T4 334-410 Sentence denotes Therefore, we must find alternative approaches to target MYC-driven cancers.
TextSentencer_T5 411-501 Sentence denotes Amplification of MYCN, a MYC family member, predicts high-risk neuroblastoma (NB) disease.
T5 411-501 Sentence denotes Amplification of MYCN, a MYC family member, predicts high-risk neuroblastoma (NB) disease.
TextSentencer_T6 502-697 Sentence denotes We have shown that R9-caPep blocks the interaction of PCNA with its binding partners and selectively kills human NB cells, especially those with MYCN amplification, and we now show the mechanism.
T6 502-697 Sentence denotes We have shown that R9-caPep blocks the interaction of PCNA with its binding partners and selectively kills human NB cells, especially those with MYCN amplification, and we now show the mechanism.
TextSentencer_T7 698-776 Sentence denotes We found elevated levels of DNA replication stress in MYCN-amplified NB cells.
T7 698-776 Sentence denotes We found elevated levels of DNA replication stress in MYCN-amplified NB cells.
TextSentencer_T8 777-1009 Sentence denotes R9-caPep exacerbated DNA replication stress in MYCN-amplified NB cells and NB cells with an augmented level of MYC by interfering with DNA replication fork extension, leading to Chk1 dependence and susceptibility to Chk1 inhibition.
T8 777-1009 Sentence denotes R9-caPep exacerbated DNA replication stress in MYCN-amplified NB cells and NB cells with an augmented level of MYC by interfering with DNA replication fork extension, leading to Chk1 dependence and susceptibility to Chk1 inhibition.
TextSentencer_T9 1010-1073 Sentence denotes We describe how these effects may be exploited for treating NB.
T9 1010-1073 Sentence denotes We describe how these effects may be exploited for treating NB.