Id |
Subject |
Object |
Predicate |
Lexical cue |
TextSentencer_T1 |
0-135 |
Sentence |
denotes |
Comparison of biological activities of human antithrombins with high-mannose or complex- type nonfucosylated N-linked oligosaccharides. |
T1 |
0-135 |
Sentence |
denotes |
Comparison of biological activities of human antithrombins with high-mannose or complex- type nonfucosylated N-linked oligosaccharides. |
T1 |
0-135 |
Sentence |
denotes |
Comparison of biological activities of human antithrombins with high-mannose or complex- type nonfucosylated N-linked oligosaccharides. |
TextSentencer_T2 |
136-286 |
Sentence |
denotes |
The structure of the N-linked oligosaccharides attached to antithrombin (AT) has been shown to affect its anticoagulant activity and pharmacokinetics. |
T2 |
136-286 |
Sentence |
denotes |
The structure of the N-linked oligosaccharides attached to antithrombin (AT) has been shown to affect its anticoagulant activity and pharmacokinetics. |
T2 |
136-286 |
Sentence |
denotes |
The structure of the N-linked oligosaccharides attached to antithrombin (AT) has been shown to affect its anticoagulant activity and pharmacokinetics. |
TextSentencer_T3 |
287-473 |
Sentence |
denotes |
Human AT has biantennary complex-type oligosaccharides with the unique feature of lacking a core fucose, which affects its biological activities by changing its heparin binding affinity. |
T3 |
287-473 |
Sentence |
denotes |
Human AT has biantennary complex-type oligosaccharides with the unique feature of lacking a core fucose, which affects its biological activities by changing its heparin binding affinity. |
T3 |
287-473 |
Sentence |
denotes |
Human AT has biantennary complex-type oligosaccharides with the unique feature of lacking a core fucose, which affects its biological activities by changing its heparin binding affinity. |
TextSentencer_T4 |
474-614 |
Sentence |
denotes |
In human plasma, AT circulates as a mixture of the α-form bearing four oligosaccharides and the β-form lacking an oligosaccharide at Asn135. |
T4 |
474-614 |
Sentence |
denotes |
In human plasma, AT circulates as a mixture of the α-form bearing four oligosaccharides and the β-form lacking an oligosaccharide at Asn135. |
T4 |
474-614 |
Sentence |
denotes |
In human plasma, AT circulates as a mixture of the α-form bearing four oligosaccharides and the β-form lacking an oligosaccharide at Asn135. |
TextSentencer_T5 |
615-758 |
Sentence |
denotes |
However, it remains unclear how the immature high-mannose-type oligosaccharides produced by mammalian cells affect biological activities of AT. |
T5 |
615-758 |
Sentence |
denotes |
However, it remains unclear how the immature high-mannose-type oligosaccharides produced by mammalian cells affect biological activities of AT. |
T5 |
615-758 |
Sentence |
denotes |
However, it remains unclear how the immature high-mannose-type oligosaccharides produced by mammalian cells affect biological activities of AT. |
TextSentencer_T6 |
759-858 |
Sentence |
denotes |
Here, we succeeded in directly comparing the activities between the high-mannose and complex-types. |
T6 |
759-858 |
Sentence |
denotes |
Here, we succeeded in directly comparing the activities between the high-mannose and complex-types. |
T6 |
759-858 |
Sentence |
denotes |
Here, we succeeded in directly comparing the activities between the high-mannose and complex-types. |
TextSentencer_T7 |
859-1015 |
Sentence |
denotes |
Interestingly, although there were no substantial differences in thrombin inhibitory activity, the high-mannose-type showed higher heparin binding affinity. |
T7 |
859-1015 |
Sentence |
denotes |
Interestingly, although there were no substantial differences in thrombin inhibitory activity, the high-mannose-type showed higher heparin binding affinity. |
T7 |
859-1015 |
Sentence |
denotes |
Interestingly, although there were no substantial differences in thrombin inhibitory activity, the high-mannose-type showed higher heparin binding affinity. |
TextSentencer_T8 |
1016-1228 |
Sentence |
denotes |
The anticoagulant activities were increased by heparin and correlated with the heparin binding affinity, resulting in the strongest anticoagulant activity being displayed in the β-form with the high-mannose-type. |
T8 |
1016-1228 |
Sentence |
denotes |
The anticoagulant activities were increased by heparin and correlated with the heparin binding affinity, resulting in the strongest anticoagulant activity being displayed in the β-form with the high-mannose-type. |
T8 |
1016-1228 |
Sentence |
denotes |
The anticoagulant activities were increased by heparin and correlated with the heparin binding affinity, resulting in the strongest anticoagulant activity being displayed in the β-form with the high-mannose-type. |
TextSentencer_T9 |
1229-1342 |
Sentence |
denotes |
In pharmacokinetic profiling, the high-mannose-type showed a much shorter plasma half-life than the complex-type. |
T9 |
1229-1342 |
Sentence |
denotes |
In pharmacokinetic profiling, the high-mannose-type showed a much shorter plasma half-life than the complex-type. |
T9 |
1229-1342 |
Sentence |
denotes |
In pharmacokinetic profiling, the high-mannose-type showed a much shorter plasma half-life than the complex-type. |
TextSentencer_T10 |
1343-1539 |
Sentence |
denotes |
The β-form was found to have a prolonged plasma half-life compared with the α-form for the high-mannose-type; conversely, the α-form showed a longer half-life than the β-form for the complex-type. |
T10 |
1343-1539 |
Sentence |
denotes |
The β-form was found to have a prolonged plasma half-life compared with the α-form for the high-mannose-type; conversely, the α-form showed a longer half-life than the β-form for the complex-type. |
T10 |
1343-1539 |
Sentence |
denotes |
The β-form was found to have a prolonged plasma half-life compared with the α-form for the high-mannose-type; conversely, the α-form showed a longer half-life than the β-form for the complex-type. |
TextSentencer_T11 |
1540-1740 |
Sentence |
denotes |
The present study highlights that AT physiological activities are strictly controlled not only by a core fucose at the reducing end but also by the high-mannose-type structures at the nonreducing end. |
T11 |
1540-1740 |
Sentence |
denotes |
The present study highlights that AT physiological activities are strictly controlled not only by a core fucose at the reducing end but also by the high-mannose-type structures at the nonreducing end. |
T11 |
1540-1740 |
Sentence |
denotes |
The present study highlights that AT physiological activities are strictly controlled not only by a core fucose at the reducing end but also by the high-mannose-type structures at the nonreducing end. |
TextSentencer_T12 |
1741-1913 |
Sentence |
denotes |
The β-form with the immature high-mannose-type appears to function as a more potent anticoagulant than the AT typically found in human plasma, once it emerges in the blood. |
T12 |
1741-1913 |
Sentence |
denotes |
The β-form with the immature high-mannose-type appears to function as a more potent anticoagulant than the AT typically found in human plasma, once it emerges in the blood. |
T12 |
1741-1913 |
Sentence |
denotes |
The β-form with the immature high-mannose-type appears to function as a more potent anticoagulant than the AT typically found in human plasma, once it emerges in the blood. |