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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-127 Sentence denotes Human placenta-derived stromal cells decrease inflammation, placental injury, and blood pressure in hypertensive pregnant mice.
T1 0-127 Sentence denotes Human placenta-derived stromal cells decrease inflammation, placental injury, and blood pressure in hypertensive pregnant mice.
TextSentencer_T2 128-382 Sentence denotes Preeclampsia, the development of hypertension and proteinuria or end-organ damage during pregnancy, is a leading cause of both maternal and fetal morbidity and mortality and there are no effective clinical treatments for preeclampsia aside from delivery.
T2 128-382 Sentence denotes Preeclampsia, the development of hypertension and proteinuria or end-organ damage during pregnancy, is a leading cause of both maternal and fetal morbidity and mortality and there are no effective clinical treatments for preeclampsia aside from delivery.
TextSentencer_T3 383-532 Sentence denotes The development of preeclampsia is characterized by maladaptation of the maternal immune system, excessive inflammation, and endothelial dysfunction.
T3 383-532 Sentence denotes The development of preeclampsia is characterized by maladaptation of the maternal immune system, excessive inflammation, and endothelial dysfunction.
TextSentencer_T4 533-703 Sentence denotes We have reported that detection of extracellular RNA by Toll-like receptors (TLRs) 3 and 7 is a key initiating signal that contributes to the development of preeclampsia.
T4 533-703 Sentence denotes We have reported that detection of extracellular RNA by Toll-like receptors (TLRs) 3 and 7 is a key initiating signal that contributes to the development of preeclampsia.
TextSentencer_T5 704-1036 Sentence denotes PLacental eXpanded (PLX-PAD; Pluristem Therapeutics, Inc., Haifa, Israel) cells are human placenta-derived, mesenchymal-like adherent stromal cells that have anti-inflammatory, pro-angiogenic, cytoprotective, and regenerative properties secondary to paracrine secretion of various molecules in response to environmental stimulation.
T5 704-1036 Sentence denotes PLacental eXpanded (PLX-PAD; Pluristem Therapeutics, Inc., Haifa, Israel) cells are human placenta-derived, mesenchymal-like adherent stromal cells that have anti-inflammatory, pro-angiogenic, cytoprotective, and regenerative properties secondary to paracrine secretion of various molecules in response to environmental stimulation.
TextSentencer_T6 1037-1217 Sentence denotes We hypothesized that PLX-PAD cells would reduce the associated inflammation and tissue damage and lower blood pressure in mice with preeclampsia induced by TLR3 or TLR7 activation.
T6 1037-1217 Sentence denotes We hypothesized that PLX-PAD cells would reduce the associated inflammation and tissue damage and lower blood pressure in mice with preeclampsia induced by TLR3 or TLR7 activation.
TextSentencer_T7 1218-1382 Sentence denotes Injection of PLX-PAD cells on gestational day 14 significantly decreased systolic blood pressure by day 17 in TLR3-induced and TLR7-induced hypertensive mice (TLR3:
T7 1218-1382 Sentence denotes Injection of PLX-PAD cells on gestational day 14 significantly decreased systolic blood pressure by day 17 in TLR3-induced and TLR7-induced hypertensive mice (TLR3:
TextSentencer_T8 1383-1408 Sentence denotes 144 to 111 mmHg and TLR7:
T8 1383-1408 Sentence denotes 144 to 111 mmHg and TLR7:
TextSentencer_T9 1409-1515 Sentence denotes 145 to 106 mmHg; both p<0.05), and also normalized their elevated urinary protein/creatinine ratios (TLR3:
T9 1409-1515 Sentence denotes 145 to 106 mmHg; both p<0.05), and also normalized their elevated urinary protein/creatinine ratios (TLR3:
TextSentencer_T10 1516-1538 Sentence denotes 5.68 to 3.72 and TLR7:
T10 1516-1538 Sentence denotes 5.68 to 3.72 and TLR7:
TextSentencer_T11 1539-1566 Sentence denotes 5.57 to 3.84; both p<0.05).
T11 1539-1566 Sentence denotes 5.57 to 3.84; both p<0.05).
TextSentencer_T12 1567-1765 Sentence denotes Gestational day 17 aortic endothelium-dependent relaxation responses improved significantly in TLR3-induced and TLR7-induced hypertensive mice who received PLX-PAD cells on gestational day 14 (TLR3:
T12 1567-1765 Sentence denotes Gestational day 17 aortic endothelium-dependent relaxation responses improved significantly in TLR3-induced and TLR7-induced hypertensive mice who received PLX-PAD cells on gestational day 14 (TLR3:
TextSentencer_T13 1766-1785 Sentence denotes 35 to 65% and TLR7:
T13 1766-1785 Sentence denotes 35 to 65% and TLR7:
TextSentencer_T14 1786-1810 Sentence denotes 37 to 63%; both p<0.05).
T14 1786-1810 Sentence denotes 37 to 63%; both p<0.05).
TextSentencer_T15 1811-1978 Sentence denotes Additionally, markers of systemic inflammation and placental injury, increased markedly in both groups of TLR-induced hypertensive mice, were reduced by PLX-PAD cells.
T15 1811-1978 Sentence denotes Additionally, markers of systemic inflammation and placental injury, increased markedly in both groups of TLR-induced hypertensive mice, were reduced by PLX-PAD cells.
TextSentencer_T16 1979-2089 Sentence denotes Importantly, PLX-PAD cell therapy had no effects on these measures in pregnant control mice or on the fetuses.
T16 1979-2089 Sentence denotes Importantly, PLX-PAD cell therapy had no effects on these measures in pregnant control mice or on the fetuses.
TextSentencer_T17 2090-2266 Sentence denotes These data demonstrate that PLX-PAD cell therapy can safely reverse preeclampsia-like features during pregnancy and have a potential therapeutic role in preeclampsia treatment.
T17 2090-2266 Sentence denotes These data demonstrate that PLX-PAD cell therapy can safely reverse preeclampsia-like features during pregnancy and have a potential therapeutic role in preeclampsia treatment.