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PubMed:26581643 / 169-1362 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
T3 0-159 Sentence denotes Huntington's disease (HD) is an autosomal dominant disorder of central nervous system caused by expansion of CAG repeats in exon1 of the huntingtin gene (Htt).
T3 0-159 Sentence denotes Huntington's disease (HD) is an autosomal dominant disorder of central nervous system caused by expansion of CAG repeats in exon1 of the huntingtin gene (Htt).
T4 160-324 Sentence denotes Among various dysfunctions originated from the mutation in Htt gene, transcriptional deregulation has been considered to be one of the most important abnormalities.
T4 160-324 Sentence denotes Among various dysfunctions originated from the mutation in Htt gene, transcriptional deregulation has been considered to be one of the most important abnormalities.
T5 325-444 Sentence denotes Large numbers of investigations identified altered expressions of genes in brains of HD patients and many models of HD.
T5 325-444 Sentence denotes Large numbers of investigations identified altered expressions of genes in brains of HD patients and many models of HD.
T6 445-756 Sentence denotes In this study we employed 2D SDS-PAGE/MALDI-MS coupled with 2D-DIGE and real-time PCR experiments of an array of genes focused to HD pathway to determine altered protein and gene expressions in STHdh(Q111)/Hdh(Q111) cells, a cell model of HD and compared with STHdh(Q7)/Hdh(Q7) cells, its wild type counterpart.
T6 445-756 Sentence denotes In this study we employed 2D SDS-PAGE/MALDI-MS coupled with 2D-DIGE and real-time PCR experiments of an array of genes focused to HD pathway to determine altered protein and gene expressions in STHdh(Q111)/Hdh(Q111) cells, a cell model of HD and compared with STHdh(Q7)/Hdh(Q7) cells, its wild type counterpart.
T7 757-987 Sentence denotes We annotated 76 proteins from these cells and observed differential expressions of 31 proteins (by 2D-DIGE) involved in processes like unfolded protein binding, negative regulation of neuron apoptosis, response to superoxides etc.
T7 757-987 Sentence denotes We annotated 76 proteins from these cells and observed differential expressions of 31 proteins (by 2D-DIGE) involved in processes like unfolded protein binding, negative regulation of neuron apoptosis, response to superoxides etc.
T8 988-1057 Sentence denotes Our PCR array experiments identified altered expressions of 47 genes.
T8 988-1057 Sentence denotes Our PCR array experiments identified altered expressions of 47 genes.
T9 1058-1193 Sentence denotes Altogether significant alteration of 77 genes/proteins could be identified in this HD cell line with potential relevance to HD biology.
T9 1058-1193 Sentence denotes Altogether significant alteration of 77 genes/proteins could be identified in this HD cell line with potential relevance to HD biology.