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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-41 Sentence denotes BIN1 regulates dynamic t-tubule membrane.
T1 0-41 Sentence denotes BIN1 regulates dynamic t-tubule membrane.
TextSentencer_T2 42-224 Sentence denotes Cardiac transverse tubules (t-tubules) are specific membrane organelles critical in calcium signaling and excitation-contraction coupling required for beat-to-beat heart contraction.
T2 42-224 Sentence denotes Cardiac transverse tubules (t-tubules) are specific membrane organelles critical in calcium signaling and excitation-contraction coupling required for beat-to-beat heart contraction.
TextSentencer_T3 225-377 Sentence denotes T-tubules are highly branched and form an interconnected network that penetrates the myocyte interior to form junctions with the sarcoplasmic reticulum.
T3 225-377 Sentence denotes T-tubules are highly branched and form an interconnected network that penetrates the myocyte interior to form junctions with the sarcoplasmic reticulum.
TextSentencer_T4 378-603 Sentence denotes T-tubules are selectively enriched with specific ion channels and proteins crucial in calcium transient development necessary in excitation-contraction coupling, thus t-tubules are a key component of cardiac myocyte function.
T4 378-603 Sentence denotes T-tubules are selectively enriched with specific ion channels and proteins crucial in calcium transient development necessary in excitation-contraction coupling, thus t-tubules are a key component of cardiac myocyte function.
TextSentencer_T5 604-801 Sentence denotes In this review, we focus primarily on two proteins concentrated within the t-tubular network, the L-type calcium channel (LTCC) and associated membrane anchor protein, bridging integrator 1 (BIN1).
T5 604-801 Sentence denotes In this review, we focus primarily on two proteins concentrated within the t-tubular network, the L-type calcium channel (LTCC) and associated membrane anchor protein, bridging integrator 1 (BIN1).
TextSentencer_T6 802-951 Sentence denotes Here, we provide an overview of current knowledge in t-tubule morphology, composition, microdomains, as well as the dynamics of the t-tubule network.
T6 802-951 Sentence denotes Here, we provide an overview of current knowledge in t-tubule morphology, composition, microdomains, as well as the dynamics of the t-tubule network.
TextSentencer_T7 952-1249 Sentence denotes Secondly, we highlight multiple aspects of BIN1-dependent t-tubule function, which includes forward trafficking of LTCCs to t-tubules, LTCC clustering at t-tubule surface, microdomain organization and regulation at t-tubule membrane, and the formation of a slow diffusion barrier within t-tubules.
T7 952-1249 Sentence denotes Secondly, we highlight multiple aspects of BIN1-dependent t-tubule function, which includes forward trafficking of LTCCs to t-tubules, LTCC clustering at t-tubule surface, microdomain organization and regulation at t-tubule membrane, and the formation of a slow diffusion barrier within t-tubules.
TextSentencer_T8 1250-1414 Sentence denotes Lastly, we describe progress in characterizing how acquired human heart failure can be attributed to abnormal BIN1 transcription and associated t-tubule remodeling.
T8 1250-1414 Sentence denotes Lastly, we describe progress in characterizing how acquired human heart failure can be attributed to abnormal BIN1 transcription and associated t-tubule remodeling.
TextSentencer_T9 1415-1614 Sentence denotes Understanding BIN1-regulated cardiac t-tubule biology in human heart failure management has the dual benefit of promoting progress in both biomarker development and therapeutic target identification.
T9 1415-1614 Sentence denotes Understanding BIN1-regulated cardiac t-tubule biology in human heart failure management has the dual benefit of promoting progress in both biomarker development and therapeutic target identification.
TextSentencer_T10 1615-1664 Sentence denotes This article is part of a Special Issue entitled:
T10 1615-1664 Sentence denotes This article is part of a Special Issue entitled:
TextSentencer_T11 1665-1687 Sentence denotes Cardiomyocyte Biology:
T11 1665-1687 Sentence denotes Cardiomyocyte Biology:
TextSentencer_T12 1688-1795 Sentence denotes Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.
T12 1688-1795 Sentence denotes Integration of Developmental and Environmental Cues in the Heart edited by Marcus Schaub and Hughes Abriel.