| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-44 |
Sentence |
denotes |
Sialic acids in cancer biology and immunity. |
| T1 |
0-44 |
Sentence |
denotes |
Sialic acids in cancer biology and immunity. |
| TextSentencer_T2 |
45-276 |
Sentence |
denotes |
During malignant transformation, glycosylation is heavily altered compared with healthy tissue due to differential expression of glycosyltransferases, glycosidases and monosaccharide transporters within the cancer microenvironment. |
| T2 |
45-276 |
Sentence |
denotes |
During malignant transformation, glycosylation is heavily altered compared with healthy tissue due to differential expression of glycosyltransferases, glycosidases and monosaccharide transporters within the cancer microenvironment. |
| TextSentencer_T3 |
277-622 |
Sentence |
denotes |
One key change of malignant tissue glycosylation is the alteration of sialic acid processing that leads to a general upregulation of sialylated glycans (hypersialylation) on cell surfaces and an increased introduction of the non-human sialic acid N-glycolyl-neuraminic acid (Neu5Gc) instead of N-acetyl-neuraminic acid into cell surface glycans. |
| T3 |
277-622 |
Sentence |
denotes |
One key change of malignant tissue glycosylation is the alteration of sialic acid processing that leads to a general upregulation of sialylated glycans (hypersialylation) on cell surfaces and an increased introduction of the non-human sialic acid N-glycolyl-neuraminic acid (Neu5Gc) instead of N-acetyl-neuraminic acid into cell surface glycans. |
| TextSentencer_T4 |
623-724 |
Sentence |
denotes |
These changes have been shown to be the result of altered sialyltransferase and sialidase expression. |
| T4 |
623-724 |
Sentence |
denotes |
These changes have been shown to be the result of altered sialyltransferase and sialidase expression. |
| TextSentencer_T5 |
725-927 |
Sentence |
denotes |
Functionally, cancer-associated hypersialylation appears to directly impact tumor cell interaction with the microenvironment, in particular the modulation of sialic acid-binding lectins on immune cells. |
| T5 |
725-927 |
Sentence |
denotes |
Functionally, cancer-associated hypersialylation appears to directly impact tumor cell interaction with the microenvironment, in particular the modulation of sialic acid-binding lectins on immune cells. |
| TextSentencer_T6 |
928-1129 |
Sentence |
denotes |
Moreover, Neu5Gc expression in human tissues enhances inflammation due to an anti-Neu5Gc immune response, which can potentially influence inflammation-induced cancer and cancer-associated inflammation. |
| T6 |
928-1129 |
Sentence |
denotes |
Moreover, Neu5Gc expression in human tissues enhances inflammation due to an anti-Neu5Gc immune response, which can potentially influence inflammation-induced cancer and cancer-associated inflammation. |
| TextSentencer_T7 |
1130-1276 |
Sentence |
denotes |
In this review, we summarize the changes of sialic acid biology within the malignant microenvironment and the resulting effect on cancer immunity. |
| T7 |
1130-1276 |
Sentence |
denotes |
In this review, we summarize the changes of sialic acid biology within the malignant microenvironment and the resulting effect on cancer immunity. |
