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PubMed:26513235 JSONTXT 7 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-102 Sentence denotes Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.
T1 0-102 Sentence denotes Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis.
TextSentencer_T2 103-259 Sentence denotes Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon production downstream of Toll-like receptor (TLR)3.
T2 103-259 Sentence denotes Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon production downstream of Toll-like receptor (TLR)3.
TextSentencer_T3 260-391 Sentence denotes In the present study, we used whole-exome sequencing to investigate the genetic profile of 16 adult patients with a history of HSE.
T3 260-391 Sentence denotes In the present study, we used whole-exome sequencing to investigate the genetic profile of 16 adult patients with a history of HSE.
TextSentencer_T4 392-565 Sentence denotes We identified novel mutations in IRF3, TYK2 and MAVS, molecules involved in generating innate antiviral immune responses, which have not previously been associated with HSE.
T4 392-565 Sentence denotes We identified novel mutations in IRF3, TYK2 and MAVS, molecules involved in generating innate antiviral immune responses, which have not previously been associated with HSE.
TextSentencer_T5 566-713 Sentence denotes Moreover, data revealed mutations in TLR3, TRIF, TBK1 and STAT1 known to be associated with HSE in children but not previously described in adults.
T5 566-713 Sentence denotes Moreover, data revealed mutations in TLR3, TRIF, TBK1 and STAT1 known to be associated with HSE in children but not previously described in adults.
TextSentencer_T6 714-986 Sentence denotes All discovered mutations were heterozygous missense mutations, the majority of which were associated with significantly decreased antiviral responses to HSV-1 infection and/or the TLR3 agonist poly(I:C) in patient peripheral blood mononuclear cells compared with controls.
T6 714-986 Sentence denotes All discovered mutations were heterozygous missense mutations, the majority of which were associated with significantly decreased antiviral responses to HSV-1 infection and/or the TLR3 agonist poly(I:C) in patient peripheral blood mononuclear cells compared with controls.
TextSentencer_T7 987-1217 Sentence denotes Altogether, this study demonstrates novel mutations in the TLR3 signaling pathway in molecules previously identified in children, suggesting that impaired innate immunity to HSV-1 may also increase susceptibility to HSE in adults.
T7 987-1217 Sentence denotes Altogether, this study demonstrates novel mutations in the TLR3 signaling pathway in molecules previously identified in children, suggesting that impaired innate immunity to HSV-1 may also increase susceptibility to HSE in adults.
TextSentencer_T8 1218-1429 Sentence denotes Importantly, the identification of mutations in innate signaling molecules not directly involved in TLR3 signaling suggests the existence of innate immunodeficiencies predisposing to HSE beyond the TLR3 pathway.
T8 1218-1429 Sentence denotes Importantly, the identification of mutations in innate signaling molecules not directly involved in TLR3 signaling suggests the existence of innate immunodeficiencies predisposing to HSE beyond the TLR3 pathway.