| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-152 |
Sentence |
denotes |
Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer. |
| T1 |
0-152 |
Sentence |
denotes |
Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer. |
| T1 |
0-152 |
Sentence |
denotes |
Structural changes in histone H2A by methylglyoxal generate highly immunogenic amorphous aggregates with implications in auto-immune response in cancer. |
| TextSentencer_T2 |
153-267 |
Sentence |
denotes |
The role of aberrant protein modifications in cancer and its diagnosis have emerged as a promising research field. |
| T2 |
153-267 |
Sentence |
denotes |
The role of aberrant protein modifications in cancer and its diagnosis have emerged as a promising research field. |
| T2 |
153-267 |
Sentence |
denotes |
The role of aberrant protein modifications in cancer and its diagnosis have emerged as a promising research field. |
| TextSentencer_T3 |
268-476 |
Sentence |
denotes |
Nonenzymatic glyco-oxidation of proteins under oxidative stress has been associated with carcinogenesis through advanced glycation end products (AGE)-receptors for advanced glycation end products (RAGE) axis. |
| T3 |
268-476 |
Sentence |
denotes |
Nonenzymatic glyco-oxidation of proteins under oxidative stress has been associated with carcinogenesis through advanced glycation end products (AGE)-receptors for advanced glycation end products (RAGE) axis. |
| T3 |
268-476 |
Sentence |
denotes |
Nonenzymatic glyco-oxidation of proteins under oxidative stress has been associated with carcinogenesis through advanced glycation end products (AGE)-receptors for advanced glycation end products (RAGE) axis. |
| TextSentencer_T4 |
477-631 |
Sentence |
denotes |
Modified proteins that are immunogenic and stimulate cellular and humoral immune responses are being studied to develop early detection markers of cancer. |
| T4 |
477-631 |
Sentence |
denotes |
Modified proteins that are immunogenic and stimulate cellular and humoral immune responses are being studied to develop early detection markers of cancer. |
| T4 |
477-631 |
Sentence |
denotes |
Modified proteins that are immunogenic and stimulate cellular and humoral immune responses are being studied to develop early detection markers of cancer. |
| TextSentencer_T5 |
632-799 |
Sentence |
denotes |
This study has probed the structural alternations; leading to the formation of adducts and aggregates, in histone H2A upon in vitro modification by methylglyoxal (MG). |
| T5 |
632-799 |
Sentence |
denotes |
This study has probed the structural alternations; leading to the formation of adducts and aggregates, in histone H2A upon in vitro modification by methylglyoxal (MG). |
| T5 |
632-799 |
Sentence |
denotes |
This study has probed the structural alternations; leading to the formation of adducts and aggregates, in histone H2A upon in vitro modification by methylglyoxal (MG). |
| TextSentencer_T6 |
800-904 |
Sentence |
denotes |
The immunogenicity of modified histone H2A and its binding with cancer autoantibodies was also assessed. |
| T6 |
800-904 |
Sentence |
denotes |
The immunogenicity of modified histone H2A and its binding with cancer autoantibodies was also assessed. |
| T6 |
800-904 |
Sentence |
denotes |
The immunogenicity of modified histone H2A and its binding with cancer autoantibodies was also assessed. |
| TextSentencer_T7 |
905-1095 |
Sentence |
denotes |
MG induced lysine side chain modifications, blocking of free amino groups and the formation of condensed cross structures in histone H2A; and its effect was inhibited by carbonyl scavengers. |
| T7 |
905-1095 |
Sentence |
denotes |
MG induced lysine side chain modifications, blocking of free amino groups and the formation of condensed cross structures in histone H2A; and its effect was inhibited by carbonyl scavengers. |
| T7 |
905-1095 |
Sentence |
denotes |
MG induced lysine side chain modifications, blocking of free amino groups and the formation of condensed cross structures in histone H2A; and its effect was inhibited by carbonyl scavengers. |
| TextSentencer_T8 |
1096-1337 |
Sentence |
denotes |
It led to the adduct formation and generation of N-epsilon-(carboxyethyl)lysine (CEL) and its decomposition forms as revealed by Matrix-assisted laser desorption ionization-mass spectrometry, high-performance liquid chromatography and LC-MS. |
| T8 |
1096-1337 |
Sentence |
denotes |
It led to the adduct formation and generation of N-epsilon-(carboxyethyl)lysine (CEL) and its decomposition forms as revealed by Matrix-assisted laser desorption ionization-mass spectrometry, high-performance liquid chromatography and LC-MS. |
| T8 |
1096-1337 |
Sentence |
denotes |
It led to the adduct formation and generation of N-epsilon-(carboxyethyl)lysine (CEL) and its decomposition forms as revealed by Matrix-assisted laser desorption ionization-mass spectrometry, high-performance liquid chromatography and LC-MS. |
| TextSentencer_T9 |
1338-1467 |
Sentence |
denotes |
MG-H2A showed amorphous aggregate formation under electron microscopy and altered binding with DNA in circular dichroism studies. |
| T9 |
1338-1467 |
Sentence |
denotes |
MG-H2A showed amorphous aggregate formation under electron microscopy and altered binding with DNA in circular dichroism studies. |
| T9 |
1338-1467 |
Sentence |
denotes |
MG-H2A showed amorphous aggregate formation under electron microscopy and altered binding with DNA in circular dichroism studies. |
| TextSentencer_T10 |
1468-1643 |
Sentence |
denotes |
The modified histone elicited high titer immunogen-specific antibodies in rabbits when compared with the native, thus pointing toward the generation of neo-epitopes in MG-H2A. |
| T10 |
1468-1643 |
Sentence |
denotes |
The modified histone elicited high titer immunogen-specific antibodies in rabbits when compared with the native, thus pointing toward the generation of neo-epitopes in MG-H2A. |
| T10 |
1468-1643 |
Sentence |
denotes |
The modified histone elicited high titer immunogen-specific antibodies in rabbits when compared with the native, thus pointing toward the generation of neo-epitopes in MG-H2A. |
| TextSentencer_T11 |
1644-1830 |
Sentence |
denotes |
The autoantibodies derived from cancer patients exhibited enhanced binding with MG-H2A as compared with the native histone in enzyme-linked immunosorbent assay and gel retardation assay. |
| T11 |
1644-1830 |
Sentence |
denotes |
The autoantibodies derived from cancer patients exhibited enhanced binding with MG-H2A as compared with the native histone in enzyme-linked immunosorbent assay and gel retardation assay. |
| T11 |
1644-1830 |
Sentence |
denotes |
The autoantibodies derived from cancer patients exhibited enhanced binding with MG-H2A as compared with the native histone in enzyme-linked immunosorbent assay and gel retardation assay. |
| TextSentencer_T12 |
1831-1907 |
Sentence |
denotes |
This reflects sharing of epitopes on MG-H2A and histones in cancer patients. |
| T12 |
1831-1907 |
Sentence |
denotes |
This reflects sharing of epitopes on MG-H2A and histones in cancer patients. |
| T12 |
1831-1907 |
Sentence |
denotes |
This reflects sharing of epitopes on MG-H2A and histones in cancer patients. |
| TextSentencer_T13 |
1908-2018 |
Sentence |
denotes |
The neo-epitopes on H2A may be responsible for induction and elevated levels of antibodies in cancer patients. |
| T13 |
1908-2018 |
Sentence |
denotes |
The neo-epitopes on H2A may be responsible for induction and elevated levels of antibodies in cancer patients. |
| T13 |
1908-2018 |
Sentence |
denotes |
The neo-epitopes on H2A may be responsible for induction and elevated levels of antibodies in cancer patients. |
| TextSentencer_T14 |
2019-2118 |
Sentence |
denotes |
Thus, MG-H2A may be considered as potential antigenic candidate for auto-immune response in cancer. |
| T14 |
2019-2118 |
Sentence |
denotes |
Thus, MG-H2A may be considered as potential antigenic candidate for auto-immune response in cancer. |
| T14 |
2019-2118 |
Sentence |
denotes |
Thus, MG-H2A may be considered as potential antigenic candidate for auto-immune response in cancer. |