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Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Comparative proteome analysis of saccular intracranial aneurysms with iTRAQ quantitative proteomics.
T1 0-100 Sentence denotes Comparative proteome analysis of saccular intracranial aneurysms with iTRAQ quantitative proteomics.
T2 101-111 Sentence denotes OBJECTIVE:
T2 101-111 Sentence denotes OBJECTIVE:
T3 112-386 Sentence denotes To screen differentially expressed proteins of saccular intracranial aneurysms and superficial temporal artery by the proteomics analysis using isobaric tags for relative and absolute quantification (iTRAQ) combined with reverse phase high-performance liquid chromatography.
T3 112-386 Sentence denotes To screen differentially expressed proteins of saccular intracranial aneurysms and superficial temporal artery by the proteomics analysis using isobaric tags for relative and absolute quantification (iTRAQ) combined with reverse phase high-performance liquid chromatography.
T4 387-395 Sentence denotes METHODS:
T4 387-395 Sentence denotes METHODS:
T5 396-536 Sentence denotes Collecting 17 samples from intracranial aneurysm patients undergoing aneurysmectomy as experiment group and 17 matched STA as control group.
T5 396-536 Sentence denotes Collecting 17 samples from intracranial aneurysm patients undergoing aneurysmectomy as experiment group and 17 matched STA as control group.
T6 537-661 Sentence denotes After quantification and enzymolysis of the protein, the iTRAQ were used to label the peptides of the 2 groups respectively.
T6 537-661 Sentence denotes After quantification and enzymolysis of the protein, the iTRAQ were used to label the peptides of the 2 groups respectively.
T7 662-796 Sentence denotes Then, the mixture of the peptides was fractioned by RP-HPLC and analyzed by LC-MS/MS to identify the differential expression proteins.
T7 662-796 Sentence denotes Then, the mixture of the peptides was fractioned by RP-HPLC and analyzed by LC-MS/MS to identify the differential expression proteins.
T8 797-805 Sentence denotes RESULTS:
T8 797-805 Sentence denotes RESULTS:
T9 806-937 Sentence denotes A total of 1699 proteins were identified from the ProteinPilot 4.5 software (AB SCIEX) using the Paragon database search algorithm.
T9 806-937 Sentence denotes A total of 1699 proteins were identified from the ProteinPilot 4.5 software (AB SCIEX) using the Paragon database search algorithm.
T10 938-1089 Sentence denotes Comparing with STA, 54 proteins were significantly up-regulated (115:114<0.5-fold) and 37 were significantly down-regulated in sIAs (115:114>2.0-fold).
T10 938-1089 Sentence denotes Comparing with STA, 54 proteins were significantly up-regulated (115:114<0.5-fold) and 37 were significantly down-regulated in sIAs (115:114>2.0-fold).
T11 1090-1385 Sentence denotes Furthermore, Integrin β3, Secreted frizzled-related protein 2 were significantly up-regulated (2.3 fold and 2.1 fold, respectively), whereas MyosinIIb, Alpha-actinin-1, Laminin β2, and Carboxypeptidase A3 were down-regulated (3.01 fold, 2.1 fold, 2.07 fold, and 2.01 fold, respectively) in sIAs.
T11 1090-1385 Sentence denotes Furthermore, Integrin β3, Secreted frizzled-related protein 2 were significantly up-regulated (2.3 fold and 2.1 fold, respectively), whereas MyosinIIb, Alpha-actinin-1, Laminin β2, and Carboxypeptidase A3 were down-regulated (3.01 fold, 2.1 fold, 2.07 fold, and 2.01 fold, respectively) in sIAs.
T12 1386-1729 Sentence denotes GO Ontology analysis showed that most differential proteins expressed in cytoskeletal; up-regulated proteins in sIAs play an important role in inflammatory reaction, enzymatic hydrolysis, cell adhesion and invasion, and cellular immune reaction; down-regulated proteins in sIAs involved in cytoskeletal protein, enzyme, and structural protein.
T12 1386-1729 Sentence denotes GO Ontology analysis showed that most differential proteins expressed in cytoskeletal; up-regulated proteins in sIAs play an important role in inflammatory reaction, enzymatic hydrolysis, cell adhesion and invasion, and cellular immune reaction; down-regulated proteins in sIAs involved in cytoskeletal protein, enzyme, and structural protein.
T13 1730-1813 Sentence denotes ITGB3, ACTN1 and MYL2 play a role in aneurysm formation via focal adhesion pathway.
T13 1730-1813 Sentence denotes ITGB3, ACTN1 and MYL2 play a role in aneurysm formation via focal adhesion pathway.
T14 1814-1911 Sentence denotes The results of Western-blot assay were consistent with the proteomic changes of those 6 proteins.
T14 1814-1911 Sentence denotes The results of Western-blot assay were consistent with the proteomic changes of those 6 proteins.
T15 1912-1923 Sentence denotes CONCLUSION:
T15 1912-1923 Sentence denotes CONCLUSION:
T16 1924-2071 Sentence denotes The differentially expressed proteins in sIAs that showed aneurysm formation are related to cytoskeleton abnormal and extracellular matrix changes.
T16 1924-2071 Sentence denotes The differentially expressed proteins in sIAs that showed aneurysm formation are related to cytoskeleton abnormal and extracellular matrix changes.
T17 2072-2190 Sentence denotes The iTRAQ technology provides scientific foundation for the further study to explore the pathogenic mechanism of sIAs.
T17 2072-2190 Sentence denotes The iTRAQ technology provides scientific foundation for the further study to explore the pathogenic mechanism of sIAs.