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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-84 Sentence denotes STAT1 modification improves therapeutic effects of interferons on lung cancer cells.
T1 0-84 Sentence denotes STAT1 modification improves therapeutic effects of interferons on lung cancer cells.
TextSentencer_T2 85-96 Sentence denotes BACKGROUND:
T2 85-96 Sentence denotes BACKGROUND:
TextSentencer_T3 97-210 Sentence denotes Interferons (IFNs) have potent anti-proliferative, pro-apoptotic, and immunomodulatory activities against cancer.
T3 97-210 Sentence denotes Interferons (IFNs) have potent anti-proliferative, pro-apoptotic, and immunomodulatory activities against cancer.
TextSentencer_T4 211-380 Sentence denotes However, the clinical utility of IFNs is limited by toxicity and pharmacokinetics making it difficult to achieve sustained therapeutic levels especially in solid tumors.
T4 211-380 Sentence denotes However, the clinical utility of IFNs is limited by toxicity and pharmacokinetics making it difficult to achieve sustained therapeutic levels especially in solid tumors.
TextSentencer_T5 381-389 Sentence denotes METHODS:
T5 381-389 Sentence denotes METHODS:
TextSentencer_T6 390-606 Sentence denotes Signal Transducer and Activator of Transcription 1 (STAT1) or a modified STAT1 (designated STAT1-CC) that is hyper-responsive to IFN were overexpressed in lung cancer SPC-A-1 and H1299 cells using lentiviral vectors.
T6 390-606 Sentence denotes Signal Transducer and Activator of Transcription 1 (STAT1) or a modified STAT1 (designated STAT1-CC) that is hyper-responsive to IFN were overexpressed in lung cancer SPC-A-1 and H1299 cells using lentiviral vectors.
TextSentencer_T7 607-704 Sentence denotes Transduction efficiency was monitored using enhanced green fluorescent protein (EGFP) expression.
T7 607-704 Sentence denotes Transduction efficiency was monitored using enhanced green fluorescent protein (EGFP) expression.
TextSentencer_T8 705-984 Sentence denotes After transduction, cells were treated with interferon-gamma (IFN-γ) or interferon-beta (IFN-β) and monitored for cell proliferation, migration, and invasiveness using Cell Counting Kit-8 and transwell chamber assays and for apoptosis using Annexin V detection by flow cytometry.
T8 705-984 Sentence denotes After transduction, cells were treated with interferon-gamma (IFN-γ) or interferon-beta (IFN-β) and monitored for cell proliferation, migration, and invasiveness using Cell Counting Kit-8 and transwell chamber assays and for apoptosis using Annexin V detection by flow cytometry.
TextSentencer_T9 985-1121 Sentence denotes In addition, levels of STAT1, STAT1 Tyr-701 phosphorylation (pSTAT1), fibronectin, and β-catenin were determined using western blotting.
T9 985-1121 Sentence denotes In addition, levels of STAT1, STAT1 Tyr-701 phosphorylation (pSTAT1), fibronectin, and β-catenin were determined using western blotting.
TextSentencer_T10 1122-1259 Sentence denotes In the case of IFN-γ stimulation, levels of S100A4, proliferating cell nuclear antigen (PCNA), and c-fos expression were also determined.
T10 1122-1259 Sentence denotes In the case of IFN-γ stimulation, levels of S100A4, proliferating cell nuclear antigen (PCNA), and c-fos expression were also determined.
TextSentencer_T11 1260-1268 Sentence denotes RESULTS:
T11 1260-1268 Sentence denotes RESULTS:
TextSentencer_T12 1269-1437 Sentence denotes We found that expression of STAT1 or STAT1-CC enhanced the effect of IFN-γ and, IFN-β on inhibition of human lung cancer cell proliferation, migration and invasiveness.
T12 1269-1437 Sentence denotes We found that expression of STAT1 or STAT1-CC enhanced the effect of IFN-γ and, IFN-β on inhibition of human lung cancer cell proliferation, migration and invasiveness.
TextSentencer_T13 1438-1555 Sentence denotes Moreover, STAT1 and STAT1-CC expression caused increases in pSTAT1 and decreases in fibronectin and β-catenin levels.
T13 1438-1555 Sentence denotes Moreover, STAT1 and STAT1-CC expression caused increases in pSTAT1 and decreases in fibronectin and β-catenin levels.
TextSentencer_T14 1556-1686 Sentence denotes STAT1-CC showed increased effects compared to STAT1 on IFN-γ induced pSTAT1 and down-regulation of S100A4, PCNA, and c-fos levels.
T14 1556-1686 Sentence denotes STAT1-CC showed increased effects compared to STAT1 on IFN-γ induced pSTAT1 and down-regulation of S100A4, PCNA, and c-fos levels.
TextSentencer_T15 1687-1698 Sentence denotes CONCLUSION:
T15 1687-1698 Sentence denotes CONCLUSION:
TextSentencer_T16 1699-1819 Sentence denotes The results show that STAT1-CC exhibited more strength in improving the antitumor response of IFNs in lung cancer cells.
T16 1699-1819 Sentence denotes The results show that STAT1-CC exhibited more strength in improving the antitumor response of IFNs in lung cancer cells.
TextSentencer_T17 1820-1983 Sentence denotes Results from this study suggest that combined treatment of IFNs and STAT1-CC might be a feasible approach for the clinical management of lung cancer in the future.
T17 1820-1983 Sentence denotes Results from this study suggest that combined treatment of IFNs and STAT1-CC might be a feasible approach for the clinical management of lung cancer in the future.