> top > projects > sentences > docs > PubMed:26347523 > annotations
sentences Home  

PubMed:26347523 JSONTXT 69 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-170 Sentence denotes Molecular mechanism of anticancer effect of Sclerotium rolfsii lectin in HT29 cells involves differential expression of genes associated with multiple signaling pathways:
T1 0-170 Sentence denotes Molecular mechanism of anticancer effect of Sclerotium rolfsii lectin in HT29 cells involves differential expression of genes associated with multiple signaling pathways:
T1 0-193 Sentence denotes Molecular mechanism of anticancer effect of Sclerotium rolfsii lectin in HT29 cells involves differential expression of genes associated with multiple signaling pathways: A microarray analysis.
TextSentencer_T2 171-193 Sentence denotes A microarray analysis.
T2 171-193 Sentence denotes A microarray analysis.
TextSentencer_T3 194-457 Sentence denotes Sclerotium rolfsii lectin (SRL) is a lectin isolated from fungus S. rolfsii and has high binding specificity toward the oncofetal Thomsen-Friedenreich carbohydrate antigen (Galβ1-3GalNAc-α-O-Ser/Thr, T or TF), which is expressed in more than 90% of human cancers.
T2 194-457 Sentence denotes Sclerotium rolfsii lectin (SRL) is a lectin isolated from fungus S. rolfsii and has high binding specificity toward the oncofetal Thomsen-Friedenreich carbohydrate antigen (Galβ1-3GalNAc-α-O-Ser/Thr, T or TF), which is expressed in more than 90% of human cancers.
T3 194-457 Sentence denotes Sclerotium rolfsii lectin (SRL) is a lectin isolated from fungus S. rolfsii and has high binding specificity toward the oncofetal Thomsen-Friedenreich carbohydrate antigen (Galβ1-3GalNAc-α-O-Ser/Thr, T or TF), which is expressed in more than 90% of human cancers.
TextSentencer_T4 458-626 Sentence denotes Our previous studies have shown that binding of SRL to human colon, breast and ovarian cancer cells induces cell apoptosis in vitro and suppresses tumor growth in vivo.
T3 458-626 Sentence denotes Our previous studies have shown that binding of SRL to human colon, breast and ovarian cancer cells induces cell apoptosis in vitro and suppresses tumor growth in vivo.
T4 458-626 Sentence denotes Our previous studies have shown that binding of SRL to human colon, breast and ovarian cancer cells induces cell apoptosis in vitro and suppresses tumor growth in vivo.
TextSentencer_T5 627-746 Sentence denotes This study investigated the SRL-mediated cell signaling in human colon cancer HT29 cells by mRNA and miRNA microarrays.
T4 627-746 Sentence denotes This study investigated the SRL-mediated cell signaling in human colon cancer HT29 cells by mRNA and miRNA microarrays.
T5 627-746 Sentence denotes This study investigated the SRL-mediated cell signaling in human colon cancer HT29 cells by mRNA and miRNA microarrays.
TextSentencer_T6 747-997 Sentence denotes It was found that SRL treatment results in altered expression of several hundred molecules including mitogen-activated protein kinase (MAPK) and c-JUN-associated, apoptosis-associated and cell cycle and DNA replication-associated signaling molecules.
T5 747-997 Sentence denotes It was found that SRL treatment results in altered expression of several hundred molecules including mitogen-activated protein kinase (MAPK) and c-JUN-associated, apoptosis-associated and cell cycle and DNA replication-associated signaling molecules.
T6 747-997 Sentence denotes It was found that SRL treatment results in altered expression of several hundred molecules including mitogen-activated protein kinase (MAPK) and c-JUN-associated, apoptosis-associated and cell cycle and DNA replication-associated signaling molecules.
TextSentencer_T7 998-1259 Sentence denotes Pathway analysis using GeneSpring 12.6.1 revealed that SRL treatment induces changes of MAPK and c-JUN-associated signaling pathways as early as 2 h while changes of cell cycle, DNA replication and apoptosis pathways were significantly affected only after 24 h.
T6 998-1259 Sentence denotes Pathway analysis using GeneSpring 12.6.1 revealed that SRL treatment induces changes of MAPK and c-JUN-associated signaling pathways as early as 2 h while changes of cell cycle, DNA replication and apoptosis pathways were significantly affected only after 24 h.
T7 998-1259 Sentence denotes Pathway analysis using GeneSpring 12.6.1 revealed that SRL treatment induces changes of MAPK and c-JUN-associated signaling pathways as early as 2 h while changes of cell cycle, DNA replication and apoptosis pathways were significantly affected only after 24 h.
TextSentencer_T8 1260-1367 Sentence denotes A significant change of cell miRNA expression was also observed after 12 h treatment of the cells with SRL.
T7 1260-1367 Sentence denotes A significant change of cell miRNA expression was also observed after 12 h treatment of the cells with SRL.
T8 1260-1367 Sentence denotes A significant change of cell miRNA expression was also observed after 12 h treatment of the cells with SRL.
TextSentencer_T9 1368-1476 Sentence denotes These changes were further validated by quantitative real time polymerase chain reaction and immunoblotting.
T8 1368-1476 Sentence denotes These changes were further validated by quantitative real time polymerase chain reaction and immunoblotting.
T9 1368-1476 Sentence denotes These changes were further validated by quantitative real time polymerase chain reaction and immunoblotting.
TextSentencer_T10 1477-1718 Sentence denotes This study thus suggests that the presence of SRL affects multiple signaling pathways in cancer cells with early effects on cell proliferation pathways associated with MAPK and c-JUN, followed by miRNA-associated cell activity and apoptosis.
T9 1477-1718 Sentence denotes This study thus suggests that the presence of SRL affects multiple signaling pathways in cancer cells with early effects on cell proliferation pathways associated with MAPK and c-JUN, followed by miRNA-associated cell activity and apoptosis.
T10 1477-1718 Sentence denotes This study thus suggests that the presence of SRL affects multiple signaling pathways in cancer cells with early effects on cell proliferation pathways associated with MAPK and c-JUN, followed by miRNA-associated cell activity and apoptosis.
TextSentencer_T11 1719-1831 Sentence denotes This provides insight information into the molecular mechanism of the anticancer activity of this fungal lectin.
T10 1719-1831 Sentence denotes This provides insight information into the molecular mechanism of the anticancer activity of this fungal lectin.
T11 1719-1831 Sentence denotes This provides insight information into the molecular mechanism of the anticancer activity of this fungal lectin.