| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-111 |
Sentence |
denotes |
Nucling, a novel apoptosis-associated protein, controls mammary gland involution by regulating NF-κB and STAT3. |
| T2 |
112-240 |
Sentence |
denotes |
Postpartum mammary gland involution is the physiological process by which the lactating gland returns to its pre-pregnant state. |
| T3 |
241-391 |
Sentence |
denotes |
In rodent models, the microenvironment of mammary gland involution is sufficient to induce enhanced tumor cell growth, local invasion, and metastasis. |
| T4 |
392-530 |
Sentence |
denotes |
Therefore, a deeper understanding of the physiological regulation of involution may provide in-depth information on breast cancer therapy. |
| T5 |
531-621 |
Sentence |
denotes |
We herein identified Nucling as an important regulator of involution of the mammary gland. |
| T6 |
622-738 |
Sentence |
denotes |
A knock-out mouse model was generated and revealed that postpartum involution were impaired in mice lacking Nucling. |
| T7 |
739-955 |
Sentence |
denotes |
Involution is normally associated with an increase in the activation of NF-κB and STAT3, which is required for the organized regulation of involution, and was observed in WT glands, but not in the absence of Nucling. |
| T8 |
956-1106 |
Sentence |
denotes |
Furthermore, the loss of Nucling led to the suppression of Calpain-1, IL-6, and C/EBPδ factors, which are known to be essential for normal involution. |
| T9 |
1107-1261 |
Sentence |
denotes |
The number of M2 macrophages, which are crucial for epithelial cell death and adipocyte repopulation after weaning, was also reduced in Nucling-KO glands. |
| T10 |
1262-1439 |
Sentence |
denotes |
Taken together, the results of the present study demonstrated that Nucling played an important role in mammary gland involution by regulating NF-κB and STAT3 signaling pathways. |
