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Id Subject Object Predicate Lexical cue
T1 0-117 Sentence denotes Conserved overlapping gene arrangement, restricted expression, and biochemical activities of DNA polymerase ν (POLN).
T2 118-201 Sentence denotes DNA polymerase ν (POLN) is one of 16 DNA polymerases encoded in vertebrate genomes.
T3 202-306 Sentence denotes It is important to determine its gene expression patterns, biological roles, and biochemical activities.
T4 307-439 Sentence denotes By quantitative analysis of mRNA expression, we found that POLN from the zebrafish Danio rerio is expressed predominantly in testis.
T5 440-527 Sentence denotes POLN is not detectably expressed in zebrafish embryos or in mouse embryonic stem cells.
T6 528-670 Sentence denotes Consistent with this, injection of POLN-specific morpholino antisense oligonucleotides did not interfere with zebrafish embryonic development.
T7 671-850 Sentence denotes Analysis of transcripts revealed that vertebrate POLN has an unusual gene expression arrangement, sharing a first exon with HAUS3, the gene encoding augmin-like complex subunit 3.
T8 851-930 Sentence denotes HAUS3 is broadly expressed in embryonic and adult tissues, in contrast to POLN.
T9 931-1060 Sentence denotes Differential expression of POLN and HAUS3 appears to arise by alternate splicing of transcripts in mammalian cells and zebrafish.
T10 1061-1322 Sentence denotes When POLN was ectopically overexpressed in human cells, it specifically coimmunoprecipitated with the homologous recombination factors BRCA1 and FANCJ, but not with previously suggested interaction partners (HELQ and members of the Fanconi anemia core complex).
T11 1323-1509 Sentence denotes Purified zebrafish POLN protein is capable of thymine glycol bypass and strand displacement, with activity dependent on a basic amino acid residue known to stabilize the primer-template.
T12 1510-1563 Sentence denotes These properties are conserved with the human enzyme.
T13 1564-1763 Sentence denotes Although the physiological function of pol ν remains to be clarified, this study uncovers distinctive aspects of its expression control and evolutionarily conserved properties of this DNA polymerase.