| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-81 |
Sentence |
denotes |
Signal Transduction and Intracellular Trafficking by the Interleukin 36 Receptor. |
| T2 |
82-237 |
Sentence |
denotes |
Improper signaling of the IL-36 receptor (IL-36R), a member of the IL-1 receptor family, has been associated with various inflammation-associated diseases. |
| T3 |
238-323 |
Sentence |
denotes |
However, the requirements for IL-36R signal transduction remain poorly characterized. |
| T4 |
324-418 |
Sentence |
denotes |
This work seeks to define the requirements for IL-36R signaling and intracellular trafficking. |
| T5 |
419-514 |
Sentence |
denotes |
In the absence of cognate agonists, IL-36R was endocytosed and recycled to the plasma membrane. |
| T6 |
515-591 |
Sentence |
denotes |
In the presence of IL-36, IL-36R increased accumulation in LAMP1+ lysosomes. |
| T7 |
592-746 |
Sentence |
denotes |
Endocytosis predominantly used a clathrin-mediated pathway, and the accumulation of the IL-36R in lysosomes did not result in increased receptor turnover. |
| T8 |
747-878 |
Sentence |
denotes |
The ubiquitin-binding Tollip protein contributed to IL-36R signaling and increased the accumulation of both subunits of the IL-36R. |
