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PubMed:26265067 JSONTXT 42 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-111 Sentence denotes Global Analysis of Protein Expression and Phosphorylation Levels in Nicotine-Treated Pancreatic Stellate Cells.
T1 0-111 Sentence denotes Global Analysis of Protein Expression and Phosphorylation Levels in Nicotine-Treated Pancreatic Stellate Cells.
TextSentencer_T2 112-269 Sentence denotes Smoking is a risk factor in pancreatic disease; however, the biochemical mechanisms correlating smoking with pancreatic dysfunction remain poorly understood.
T2 112-269 Sentence denotes Smoking is a risk factor in pancreatic disease; however, the biochemical mechanisms correlating smoking with pancreatic dysfunction remain poorly understood.
TextSentencer_T3 270-409 Sentence denotes Strategies using multiplexed isobaric tag-based mass spectrometry facilitate the study of drug-induced perturbations on biological systems.
T3 270-409 Sentence denotes Strategies using multiplexed isobaric tag-based mass spectrometry facilitate the study of drug-induced perturbations on biological systems.
TextSentencer_T4 410-644 Sentence denotes Here, we present the first large-scale analysis of the proteomic and phosphoproteomic alterations in pancreatic stellate cells following treatment with two nicotinic acetylcholine receptor (nAChR) ligands: nicotine and α-bungarotoxin.
T4 410-644 Sentence denotes Here, we present the first large-scale analysis of the proteomic and phosphoproteomic alterations in pancreatic stellate cells following treatment with two nicotinic acetylcholine receptor (nAChR) ligands: nicotine and α-bungarotoxin.
TextSentencer_T5 645-863 Sentence denotes We treated cells with nicotine or α-bungarotoxin for 12 h in triplicate and compared alterations in protein expression and phosphorylation levels to mock-treated cells using a tandem mass tag (TMT9plex)-based approach.
T5 645-863 Sentence denotes We treated cells with nicotine or α-bungarotoxin for 12 h in triplicate and compared alterations in protein expression and phosphorylation levels to mock-treated cells using a tandem mass tag (TMT9plex)-based approach.
TextSentencer_T6 864-991 Sentence denotes Over 8100 proteins were quantified across all nine samples, of which 46 were altered in abundance upon treatment with nicotine.
T6 864-991 Sentence denotes Over 8100 proteins were quantified across all nine samples, of which 46 were altered in abundance upon treatment with nicotine.
TextSentencer_T7 992-1143 Sentence denotes Proteins with increased abundance included those associated with neurons, defense mechanisms, indicators of pancreatic disease, and lysosomal proteins.
T7 992-1143 Sentence denotes Proteins with increased abundance included those associated with neurons, defense mechanisms, indicators of pancreatic disease, and lysosomal proteins.
TextSentencer_T8 1144-1364 Sentence denotes In addition, we measured differences for ∼16 000 phosphorylation sites across all nine samples using a titanium dioxide-based strategy, of which 132 sites were altered with nicotine and 451 with α-bungarotoxin treatment.
T8 1144-1364 Sentence denotes In addition, we measured differences for ∼16 000 phosphorylation sites across all nine samples using a titanium dioxide-based strategy, of which 132 sites were altered with nicotine and 451 with α-bungarotoxin treatment.
TextSentencer_T9 1365-1461 Sentence denotes Many altered phosphorylation sites were involved in nuclear function and transcriptional events.
T9 1365-1461 Sentence denotes Many altered phosphorylation sites were involved in nuclear function and transcriptional events.
TextSentencer_T10 1462-1640 Sentence denotes This study supports the development of future targeted investigations to establish a better understanding for the role of nicotine and associated receptors in pancreatic disease.
T10 1462-1640 Sentence denotes This study supports the development of future targeted investigations to establish a better understanding for the role of nicotine and associated receptors in pancreatic disease.