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PubMed:26212080 JSONTXT 8 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-92 Sentence denotes Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.
T1 0-92 Sentence denotes Tetraspanin 3 Is Required for the Development and Propagation of Acute Myelogenous Leukemia.
TextSentencer_T2 93-227 Sentence denotes Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy.
T2 93-227 Sentence denotes Acute Myelogenous Leukemia (AML) is an aggressive cancer that strikes both adults and children and is frequently resistant to therapy.
TextSentencer_T3 228-359 Sentence denotes Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease.
T3 228-359 Sentence denotes Thus, identifying signals needed for AML propagation is a critical step toward developing new approaches for treating this disease.
TextSentencer_T4 360-473 Sentence denotes Here, we show that Tetraspanin 3 is a target of the RNA binding protein Musashi 2, which plays a key role in AML.
T4 360-473 Sentence denotes Here, we show that Tetraspanin 3 is a target of the RNA binding protein Musashi 2, which plays a key role in AML.
TextSentencer_T5 474-545 Sentence denotes We generated Tspan3 knockout mice that were born without overt defects.
T5 474-545 Sentence denotes We generated Tspan3 knockout mice that were born without overt defects.
TextSentencer_T6 546-690 Sentence denotes However, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and markedly improved survival in mouse models of AML.
T6 546-690 Sentence denotes However, Tspan3 deletion impaired leukemia stem cell self-renewal and disease propagation and markedly improved survival in mouse models of AML.
TextSentencer_T7 691-820 Sentence denotes Additionally, Tspan3 inhibition blocked growth of AML patient samples, suggesting that Tspan3 is also important in human disease.
T7 691-820 Sentence denotes Additionally, Tspan3 inhibition blocked growth of AML patient samples, suggesting that Tspan3 is also important in human disease.
TextSentencer_T8 821-969 Sentence denotes As part of the mechanism, we show that Tspan3 deficiency disabled responses to CXCL12/SDF-1 and led to defects in AML localization within the niche.
T8 821-969 Sentence denotes As part of the mechanism, we show that Tspan3 deficiency disabled responses to CXCL12/SDF-1 and led to defects in AML localization within the niche.
TextSentencer_T9 970-1089 Sentence denotes These identify Tspan3 as an important regulator of aggressive leukemias and highlight a role for Tspan3 in oncogenesis.
T9 970-1089 Sentence denotes These identify Tspan3 as an important regulator of aggressive leukemias and highlight a role for Tspan3 in oncogenesis.