| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-102 |
Sentence |
denotes |
Autophagy Protects against Colitis by the Maintenance of Normal Gut Microflora and Secretion of Mucus. |
| T2 |
103-231 |
Sentence |
denotes |
Genome-wide association studies of inflammatory bowel diseases identified susceptible loci containing an autophagy-related gene. |
| T3 |
232-344 |
Sentence |
denotes |
However, the role of autophagy in the colon, a major affected area in inflammatory bowel diseases, is not clear. |
| T4 |
345-572 |
Sentence |
denotes |
Here, we show that colonic epithelial cell-specific autophagy-related gene 7 (Atg7) conditional knock-out (cKO) mice showed exacerbation of experimental colitis with more abundant bacterial invasion into the colonic epithelium. |
| T5 |
573-678 |
Sentence |
denotes |
Quantitative PCR analysis revealed that cKO mice had abnormal microflora with an increase of some genera. |
| T6 |
679-892 |
Sentence |
denotes |
Consistently, expression of antimicrobial or antiparasitic peptides such as angiogenin-4, Relmβ, intelectin-1, and intelectin-2 as well as that of their inducer cytokines was significantly reduced in the cKO mice. |
| T7 |
893-1042 |
Sentence |
denotes |
Furthermore, secretion of colonic mucins that function as a mucosal barrier against bacterial invasion was also significantly diminished in cKO mice. |
| T8 |
1043-1215 |
Sentence |
denotes |
Taken together, our results indicate that autophagy in colonic epithelial cells protects against colitis by the maintenance of normal gut microflora and secretion of mucus. |
