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PubMed:25818725 JSONTXT 41 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-218 Sentence denotes Comparative proteomic analysis of lung tissue from guinea pigs with leptospiral pulmonary haemorrhage syndrome (LPHS) reveals a decrease in abundance of host proteins involved in cytoskeletal and cellular organization.
T1 0-218 Sentence denotes Comparative proteomic analysis of lung tissue from guinea pigs with leptospiral pulmonary haemorrhage syndrome (LPHS) reveals a decrease in abundance of host proteins involved in cytoskeletal and cellular organization.
TextSentencer_T2 219-230 Sentence denotes UNLABELLED:
T2 219-230 Sentence denotes UNLABELLED:
TextSentencer_T3 231-328 Sentence denotes Leptospiral pulmonary haemorrhage syndrome (LPHS) is a particularly severe form of leptospirosis.
T3 231-328 Sentence denotes Leptospiral pulmonary haemorrhage syndrome (LPHS) is a particularly severe form of leptospirosis.
TextSentencer_T4 329-485 Sentence denotes LPHS is increasingly recognized in both humans and animals and is characterized by rapidly progressive intra-alveolar haemorrhage leading to high mortality.
T4 329-485 Sentence denotes LPHS is increasingly recognized in both humans and animals and is characterized by rapidly progressive intra-alveolar haemorrhage leading to high mortality.
TextSentencer_T5 486-603 Sentence denotes The pathogenic mechanisms of LPHS are poorly understood which hampers the application of effective treatment regimes.
T5 486-603 Sentence denotes The pathogenic mechanisms of LPHS are poorly understood which hampers the application of effective treatment regimes.
TextSentencer_T6 604-723 Sentence denotes In this study a 2-D guinea pig proteome lung map was created and used to investigate the pathogenic mechanisms of LPHS.
T6 604-723 Sentence denotes In this study a 2-D guinea pig proteome lung map was created and used to investigate the pathogenic mechanisms of LPHS.
TextSentencer_T7 724-924 Sentence denotes Comparison of lung proteomes from infected and non-infected guinea pigs via differential in-gel electrophoresis revealed highly significant differences in abundance of proteins contained in 130 spots.
T7 724-924 Sentence denotes Comparison of lung proteomes from infected and non-infected guinea pigs via differential in-gel electrophoresis revealed highly significant differences in abundance of proteins contained in 130 spots.
TextSentencer_T8 925-1113 Sentence denotes Acute phase proteins were the largest functional group amongst proteins with increased abundance in LPHS lung tissue, and likely reflect a local and/or systemic host response to infection.
T8 925-1113 Sentence denotes Acute phase proteins were the largest functional group amongst proteins with increased abundance in LPHS lung tissue, and likely reflect a local and/or systemic host response to infection.
TextSentencer_T9 1114-1478 Sentence denotes The observed decrease in abundance of proteins involved in cytoskeletal and cellular organization in LPHS lung tissue further suggests that infection with pathogenic Leptospira induces changes in the abundance of host proteins involved in cellular architecture and adhesion contributing to the dramatically increased alveolar septal wall permeability seen in LPHS.
T9 1114-1478 Sentence denotes The observed decrease in abundance of proteins involved in cytoskeletal and cellular organization in LPHS lung tissue further suggests that infection with pathogenic Leptospira induces changes in the abundance of host proteins involved in cellular architecture and adhesion contributing to the dramatically increased alveolar septal wall permeability seen in LPHS.
TextSentencer_T10 1479-1503 Sentence denotes BIOLOGICAL SIGNIFICANCE:
T10 1479-1503 Sentence denotes BIOLOGICAL SIGNIFICANCE:
TextSentencer_T11 1504-1700 Sentence denotes The recent completion of the complete genome sequence of the guinea pig (Cavia porcellus) provides innovative opportunities to apply proteomic technologies to an important animal model of disease.
T11 1504-1700 Sentence denotes The recent completion of the complete genome sequence of the guinea pig (Cavia porcellus) provides innovative opportunities to apply proteomic technologies to an important animal model of disease.
TextSentencer_T12 1701-2086 Sentence denotes In this study, the comparative proteomic analysis of lung tissue from experimentally infected guinea pigs with leptospiral pulmonary haemorrhage syndrome (LPHS) revealed a decrease in abundance of proteins involved in cellular architecture and adhesion, suggesting that loss or down-regulation of cytoskeletal and adhesion molecules plays an important role in the pathogenesis of LPHS.
T12 1701-2086 Sentence denotes In this study, the comparative proteomic analysis of lung tissue from experimentally infected guinea pigs with leptospiral pulmonary haemorrhage syndrome (LPHS) revealed a decrease in abundance of proteins involved in cellular architecture and adhesion, suggesting that loss or down-regulation of cytoskeletal and adhesion molecules plays an important role in the pathogenesis of LPHS.
TextSentencer_T13 2087-2213 Sentence denotes A publically available guinea pig lung proteome map was constructed to facilitate future pulmonary proteomics in this species.
T13 2087-2213 Sentence denotes A publically available guinea pig lung proteome map was constructed to facilitate future pulmonary proteomics in this species.