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PubMed:25732040 JSONTXT 14 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-122 Sentence denotes Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome.
T1 0-122 Sentence denotes Glioblastoma adaptation traced through decline of an IDH1 clonal driver and macro-evolution of a double-minute chromosome.
TextSentencer_T2 123-134 Sentence denotes BACKGROUND:
T2 123-134 Sentence denotes BACKGROUND:
TextSentencer_T3 135-283 Sentence denotes Glioblastoma (GBM) is the most common malignant brain cancer occurring in adults, and is associated with dismal outcome and few therapeutic options.
T3 135-283 Sentence denotes Glioblastoma (GBM) is the most common malignant brain cancer occurring in adults, and is associated with dismal outcome and few therapeutic options.
TextSentencer_T4 284-430 Sentence denotes GBM has been shown to predominantly disrupt three core pathways through somatic aberrations, rendering it ideal for precision medicine approaches.
T4 284-430 Sentence denotes GBM has been shown to predominantly disrupt three core pathways through somatic aberrations, rendering it ideal for precision medicine approaches.
TextSentencer_T5 431-439 Sentence denotes METHODS:
T5 431-439 Sentence denotes METHODS:
TextSentencer_T6 440-620 Sentence denotes We describe a 35-year-old female patient with recurrent GBM following surgical removal of the primary tumour, adjuvant treatment with temozolomide and a 3-year disease-free period.
T6 440-620 Sentence denotes We describe a 35-year-old female patient with recurrent GBM following surgical removal of the primary tumour, adjuvant treatment with temozolomide and a 3-year disease-free period.
TextSentencer_T7 621-789 Sentence denotes Rapid whole-genome sequencing (WGS) of three separate tumour regions at recurrence was carried out and interpreted relative to WGS of two regions of the primary tumour.
T7 621-789 Sentence denotes Rapid whole-genome sequencing (WGS) of three separate tumour regions at recurrence was carried out and interpreted relative to WGS of two regions of the primary tumour.
TextSentencer_T8 790-798 Sentence denotes RESULTS:
T8 790-798 Sentence denotes RESULTS:
TextSentencer_T9 799-885 Sentence denotes We found extensive mutational and copy-number heterogeneity within the primary tumour.
T9 799-885 Sentence denotes We found extensive mutational and copy-number heterogeneity within the primary tumour.
TextSentencer_T10 886-1001 Sentence denotes We identified a TP53 mutation and two focal amplifications involving PDGFRA, KIT and CDK4, on chromosomes 4 and 12.
T10 886-1001 Sentence denotes We identified a TP53 mutation and two focal amplifications involving PDGFRA, KIT and CDK4, on chromosomes 4 and 12.
TextSentencer_T11 1002-1139 Sentence denotes A clonal IDH1 R132H mutation in the primary, a known GBM driver event, was detectable at only very low frequency in the recurrent tumour.
T11 1002-1139 Sentence denotes A clonal IDH1 R132H mutation in the primary, a known GBM driver event, was detectable at only very low frequency in the recurrent tumour.
TextSentencer_T12 1140-1372 Sentence denotes After sub-clonal diversification, evidence was found for a whole-genome doubling event and a translocation between the amplified regions of PDGFRA, KIT and CDK4, encoded within a double-minute chromosome also incorporating miR26a-2.
T12 1140-1372 Sentence denotes After sub-clonal diversification, evidence was found for a whole-genome doubling event and a translocation between the amplified regions of PDGFRA, KIT and CDK4, encoded within a double-minute chromosome also incorporating miR26a-2.
TextSentencer_T13 1373-1639 Sentence denotes The WGS analysis uncovered progressive evolution of the double-minute chromosome converging on the KIT/PDGFRA/PI3K/mTOR axis, superseding the IDH1 mutation in dominance in a mutually exclusive manner at recurrence, consequently the patient was treated with imatinib.
T13 1373-1639 Sentence denotes The WGS analysis uncovered progressive evolution of the double-minute chromosome converging on the KIT/PDGFRA/PI3K/mTOR axis, superseding the IDH1 mutation in dominance in a mutually exclusive manner at recurrence, consequently the patient was treated with imatinib.
TextSentencer_T14 1640-1786 Sentence denotes Despite rapid sequencing and cancer genome-guided therapy against amplified oncogenes, the disease progressed, and the patient died shortly after.
T14 1640-1786 Sentence denotes Despite rapid sequencing and cancer genome-guided therapy against amplified oncogenes, the disease progressed, and the patient died shortly after.
TextSentencer_T15 1787-1798 Sentence denotes CONCLUSION:
T15 1787-1798 Sentence denotes CONCLUSION:
TextSentencer_T16 1799-2016 Sentence denotes This case sheds light on the dynamic evolution of a GBM tumour, defining the origins of the lethal sub-clone, the macro-evolutionary genomic events dominating the disease at recurrence and the loss of a clonal driver.
T16 1799-2016 Sentence denotes This case sheds light on the dynamic evolution of a GBM tumour, defining the origins of the lethal sub-clone, the macro-evolutionary genomic events dominating the disease at recurrence and the loss of a clonal driver.
TextSentencer_T17 2017-2141 Sentence denotes Even in the era of rapid WGS analysis, cases such as this illustrate the significant hurdles for precision medicine success.
T17 2017-2141 Sentence denotes Even in the era of rapid WGS analysis, cases such as this illustrate the significant hurdles for precision medicine success.