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PubMed:2572590 JSONTXT 27 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-110 Sentence denotes Hereditary alpha 2-plasmin inhibitor deficiency caused by a transport-deficient mutation (alpha 2-PI-Okinawa).
T1 0-110 Sentence denotes Hereditary alpha 2-plasmin inhibitor deficiency caused by a transport-deficient mutation (alpha 2-PI-Okinawa).
T2 111-189 Sentence denotes Deletion of Glu137 by a trinucleotide deletion blocks intracellular transport.
T2 111-189 Sentence denotes Deletion of Glu137 by a trinucleotide deletion blocks intracellular transport.
T3 190-343 Sentence denotes alpha 2-Plasmin inhibitor is the most important physiological inhibitor of fibrinolysis; hence, its deficiency results in a severe hemorrhagic diathesis.
T3 190-343 Sentence denotes alpha 2-Plasmin inhibitor is the most important physiological inhibitor of fibrinolysis; hence, its deficiency results in a severe hemorrhagic diathesis.
T4 344-466 Sentence denotes We have cloned and characterized a mutant alpha 2-plasmin inhibitor gene from an individual homozygous for the deficiency.
T4 344-466 Sentence denotes We have cloned and characterized a mutant alpha 2-plasmin inhibitor gene from an individual homozygous for the deficiency.
T5 467-629 Sentence denotes By sequencing all the coding exons and exon-intron boundaries of the gene, a trinucleotide deletion in exon VII that results in deletion of Glu137 was identified.
T5 467-629 Sentence denotes By sequencing all the coding exons and exon-intron boundaries of the gene, a trinucleotide deletion in exon VII that results in deletion of Glu137 was identified.
T6 630-699 Sentence denotes We have designated this variant as alpha 2-plasmin inhibitor Okinawa.
T6 630-699 Sentence denotes We have designated this variant as alpha 2-plasmin inhibitor Okinawa.
T7 700-912 Sentence denotes Using DNA samples amplified with the polymerase chain reaction, hybridization analysis by oligonucleotide probes confirmed the presence of this mutation in all the affected family members, including both parents.
T7 700-912 Sentence denotes Using DNA samples amplified with the polymerase chain reaction, hybridization analysis by oligonucleotide probes confirmed the presence of this mutation in all the affected family members, including both parents.
T8 913-1158 Sentence denotes To elucidate the mechanism by which this mutation leads to the deficiency, a eukaryotic expression plasmid for alpha 2-plasmin inhibitor containing this mutation was constructed and transfected into COS-7 cells for transient expression analysis.
T8 913-1158 Sentence denotes To elucidate the mechanism by which this mutation leads to the deficiency, a eukaryotic expression plasmid for alpha 2-plasmin inhibitor containing this mutation was constructed and transfected into COS-7 cells for transient expression analysis.
T9 1159-1458 Sentence denotes Immunoprecipitation analysis and enzyme-linked immunosorbent assay revealed that the mutant alpha 2-plasmin inhibitor synthesized is mostly retained within the cells as an endoglycosidase H-sensitive form, and only a small portion of it is secreted into the medium as a neuraminidase-sensitive form.
T9 1159-1458 Sentence denotes Immunoprecipitation analysis and enzyme-linked immunosorbent assay revealed that the mutant alpha 2-plasmin inhibitor synthesized is mostly retained within the cells as an endoglycosidase H-sensitive form, and only a small portion of it is secreted into the medium as a neuraminidase-sensitive form.
T10 1459-1658 Sentence denotes These results suggest that the Glu137 deletion leads to the alpha 2-plasmin inhibitor deficiency by causing a block in its intracellular transport from the endoplasmic reticulum to the Golgi complex.
T10 1459-1658 Sentence denotes These results suggest that the Glu137 deletion leads to the alpha 2-plasmin inhibitor deficiency by causing a block in its intracellular transport from the endoplasmic reticulum to the Golgi complex.