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PubMed:25675535 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-101 Sentence denotes Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
T1 0-101 Sentence denotes Silencing LRH-1 in colon cancer cell lines impairs proliferation and alters gene expression programs.
TextSentencer_T2 102-200 Sentence denotes Colorectal cancers (CRCs) account for nearly 10% of all cancer deaths in industrialized countries.
T2 102-200 Sentence denotes Colorectal cancers (CRCs) account for nearly 10% of all cancer deaths in industrialized countries.
TextSentencer_T3 201-328 Sentence denotes Recent evidence points to a central role for the nuclear receptor liver receptor homolog-1 (LRH-1) in intestinal tumorigenesis.
T3 201-328 Sentence denotes Recent evidence points to a central role for the nuclear receptor liver receptor homolog-1 (LRH-1) in intestinal tumorigenesis.
TextSentencer_T4 329-509 Sentence denotes Interaction of LRH-1 with the Wnt/β-catenin pathway, highly active in a critical subpopulation of CRC cells, underscores the importance of elucidating LRH-1's role in this disease.
T4 329-509 Sentence denotes Interaction of LRH-1 with the Wnt/β-catenin pathway, highly active in a critical subpopulation of CRC cells, underscores the importance of elucidating LRH-1's role in this disease.
TextSentencer_T5 510-679 Sentence denotes Reduction of LRH-1 diminishes tumor burden in murine models of CRC; however, it is not known whether LRH-1 is required for tumorigenesis, for proliferation, or for both.
T5 510-679 Sentence denotes Reduction of LRH-1 diminishes tumor burden in murine models of CRC; however, it is not known whether LRH-1 is required for tumorigenesis, for proliferation, or for both.
TextSentencer_T6 680-791 Sentence denotes In this work, we address this question through shRNA-mediated silencing of LRH-1 in established CRC cell lines.
T6 680-791 Sentence denotes In this work, we address this question through shRNA-mediated silencing of LRH-1 in established CRC cell lines.
TextSentencer_T7 792-980 Sentence denotes LRH-1 mRNA knockdown results in significantly impaired proliferation in a cell line highly expressing the receptor and more modest impairment in a cell line with moderate LRH-1 expression.
T7 792-980 Sentence denotes LRH-1 mRNA knockdown results in significantly impaired proliferation in a cell line highly expressing the receptor and more modest impairment in a cell line with moderate LRH-1 expression.
TextSentencer_T8 981-1112 Sentence denotes Cell-cycle analysis shows prolongation of G0/G1 with LRH-1 silencing, consistent with LRH-1 cell-cycle influences in other tissues.
T8 981-1112 Sentence denotes Cell-cycle analysis shows prolongation of G0/G1 with LRH-1 silencing, consistent with LRH-1 cell-cycle influences in other tissues.
TextSentencer_T9 1113-1338 Sentence denotes Cluster analysis of microarray gene expression demonstrates significant genome wide alterations with major effects in cell-cycle regulation, signal transduction, bile acid and cholesterol metabolism, and control of apoptosis.
T9 1113-1338 Sentence denotes Cluster analysis of microarray gene expression demonstrates significant genome wide alterations with major effects in cell-cycle regulation, signal transduction, bile acid and cholesterol metabolism, and control of apoptosis.
TextSentencer_T10 1339-1445 Sentence denotes This study demonstrates a critical proproliferative role for LRH-1 in established colon cancer cell lines.
T10 1339-1445 Sentence denotes This study demonstrates a critical proproliferative role for LRH-1 in established colon cancer cell lines.
TextSentencer_T11 1446-1503 Sentence denotes LRH-1 exerts its effects via multiple signaling networks.
T11 1446-1503 Sentence denotes LRH-1 exerts its effects via multiple signaling networks.
TextSentencer_T12 1504-1587 Sentence denotes Our results suggest that selected CRC patients could benefit from LRH-1 inhibitors.
T12 1504-1587 Sentence denotes Our results suggest that selected CRC patients could benefit from LRH-1 inhibitors.