| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-63 |
Sentence |
denotes |
A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis. |
| T1 |
0-63 |
Sentence |
denotes |
A mouse model of KIF5B-RET fusion-dependent lung tumorigenesis. |
| TextSentencer_T2 |
64-322 |
Sentence |
denotes |
Oncogenic fusion of the RET (rearranged during transfection) gene was recently identified as a novel driver gene aberration not only for the development of thyroid carcinoma but also of lung adenocarcinoma, the most frequent histological type of lung cancer. |
| T2 |
64-322 |
Sentence |
denotes |
Oncogenic fusion of the RET (rearranged during transfection) gene was recently identified as a novel driver gene aberration not only for the development of thyroid carcinoma but also of lung adenocarcinoma, the most frequent histological type of lung cancer. |
| TextSentencer_T3 |
323-537 |
Sentence |
denotes |
This study constructed and analyzed transgenic mice expressing KIF5B-RET, the predominant form of RET fusion gene specific for lung adenocarcinoma, under the control of the SPC (surfactant protein C) gene promoter. |
| T3 |
323-537 |
Sentence |
denotes |
This study constructed and analyzed transgenic mice expressing KIF5B-RET, the predominant form of RET fusion gene specific for lung adenocarcinoma, under the control of the SPC (surfactant protein C) gene promoter. |
| TextSentencer_T4 |
538-674 |
Sentence |
denotes |
The mice expressed the KIF5B-RET fusion gene specifically in lung alveolar epithelial cells, and developed multiple tumors in the lungs. |
| T4 |
538-674 |
Sentence |
denotes |
The mice expressed the KIF5B-RET fusion gene specifically in lung alveolar epithelial cells, and developed multiple tumors in the lungs. |
| TextSentencer_T5 |
675-786 |
Sentence |
denotes |
Treatment of the transgenic mice with vandetanib, which is a RET tyrosine kinase inhibitor approved by the U.S. |
| T5 |
675-786 |
Sentence |
denotes |
Treatment of the transgenic mice with vandetanib, which is a RET tyrosine kinase inhibitor approved by the U.S. |
| TextSentencer_T6 |
787-1014 |
Sentence |
denotes |
Food and Drug Administration for the treatment of thyroid carcinoma, for 8 or 20 weeks led to a marked reduction in the number of lung tumors (3.3 versus 0 and 6.5 versus 0.2 per tissue section, respectively; P < 0.01, t-test). |
| T6 |
787-1014 |
Sentence |
denotes |
Food and Drug Administration for the treatment of thyroid carcinoma, for 8 or 20 weeks led to a marked reduction in the number of lung tumors (3.3 versus 0 and 6.5 versus 0.2 per tissue section, respectively; P < 0.01, t-test). |
| TextSentencer_T7 |
1015-1173 |
Sentence |
denotes |
The results suggest that the RET fusion functions as a driver for the development of lung tumors, whose growth is inhibited by RET tyrosine kinase inhibitors. |
| T7 |
1015-1173 |
Sentence |
denotes |
The results suggest that the RET fusion functions as a driver for the development of lung tumors, whose growth is inhibited by RET tyrosine kinase inhibitors. |