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PubMed:25056937 JSONTXT 18 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-102 Sentence denotes Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer.
T1 0-102 Sentence denotes Inhibition of circulating dipeptidyl peptidase 4 activity in patients with metastatic prostate cancer.
TextSentencer_T2 103-190 Sentence denotes Cancer is responsible for many deaths and is a major source of healthcare expenditures.
T2 103-190 Sentence denotes Cancer is responsible for many deaths and is a major source of healthcare expenditures.
TextSentencer_T3 191-340 Sentence denotes The identification of new, non-invasive biomarkers might allow improvement of the direct diagnostic or prognostic ability of already available tools.
T3 191-340 Sentence denotes The identification of new, non-invasive biomarkers might allow improvement of the direct diagnostic or prognostic ability of already available tools.
TextSentencer_T4 341-598 Sentence denotes Here, we took the innovative approach of interrogating the activity of exopeptidases in the serum of cancer patients with the aim of establishing a distinction based on enzymatic function, instead of simple protein levels, as a means to biomarker discovery.
T4 341-598 Sentence denotes Here, we took the innovative approach of interrogating the activity of exopeptidases in the serum of cancer patients with the aim of establishing a distinction based on enzymatic function, instead of simple protein levels, as a means to biomarker discovery.
TextSentencer_T5 599-854 Sentence denotes We first analyzed two well-characterized mouse models of prostate cancer, each with a distinct genetic lesion, and established that broad exopeptidase and targeted aminopeptidase activity tests reveal proteolytic changes associated with tumor development.
T5 599-854 Sentence denotes We first analyzed two well-characterized mouse models of prostate cancer, each with a distinct genetic lesion, and established that broad exopeptidase and targeted aminopeptidase activity tests reveal proteolytic changes associated with tumor development.
TextSentencer_T6 855-1084 Sentence denotes We also describe new peptide-based freeze-frame reagents uniquely suited to probe the altered balance of selected aminopeptidases, as opposed to the full array of exopeptidases, and/or their modulators in patient serum or plasma.
T6 855-1084 Sentence denotes We also describe new peptide-based freeze-frame reagents uniquely suited to probe the altered balance of selected aminopeptidases, as opposed to the full array of exopeptidases, and/or their modulators in patient serum or plasma.
TextSentencer_T7 1085-1205 Sentence denotes One particular proteolytic activity was impaired in animals with aggressive disease relative to cancer-free littermates.
T7 1085-1205 Sentence denotes One particular proteolytic activity was impaired in animals with aggressive disease relative to cancer-free littermates.
TextSentencer_T8 1206-1363 Sentence denotes We identified the protease in question as dipeptidyl peptidase 4 (DPP4) by analyzing selected knockout mice and evaluating the effect of specific inhibitors.
T8 1206-1363 Sentence denotes We identified the protease in question as dipeptidyl peptidase 4 (DPP4) by analyzing selected knockout mice and evaluating the effect of specific inhibitors.
TextSentencer_T9 1364-1515 Sentence denotes DPP4 activity was also reduced in the sera of patients with metastatic prostate cancer relative to patients with localized disease or healthy controls.
T9 1364-1515 Sentence denotes DPP4 activity was also reduced in the sera of patients with metastatic prostate cancer relative to patients with localized disease or healthy controls.
TextSentencer_T10 1516-1672 Sentence denotes However, no significant differences in DPP4 serum levels were observed, which established the loss of activity as the result of impaired enzymatic function.
T10 1516-1672 Sentence denotes However, no significant differences in DPP4 serum levels were observed, which established the loss of activity as the result of impaired enzymatic function.
TextSentencer_T11 1673-1852 Sentence denotes Biochemical analysis indicated that reduced activity was the result not of post-translational modifications or allosteric changes, but instead of a low-molecular-weight inhibitor.
T11 1673-1852 Sentence denotes Biochemical analysis indicated that reduced activity was the result not of post-translational modifications or allosteric changes, but instead of a low-molecular-weight inhibitor.
TextSentencer_T12 1853-1988 Sentence denotes After we adjusted for age and total prostate-specific antigen, reduced DPP4 activity remained a significant predictor of cancer status.
T12 1853-1988 Sentence denotes After we adjusted for age and total prostate-specific antigen, reduced DPP4 activity remained a significant predictor of cancer status.
TextSentencer_T13 1989-2270 Sentence denotes The results of this proof-of-principle study suggest that DPP4 activity might be a potential blood-based indicator of the presence of metastatic cancer of prostatic origin, either by itself or, more likely, as a means to improve the sensitivity and specificity of existing markers.
T13 1989-2270 Sentence denotes The results of this proof-of-principle study suggest that DPP4 activity might be a potential blood-based indicator of the presence of metastatic cancer of prostatic origin, either by itself or, more likely, as a means to improve the sensitivity and specificity of existing markers.