| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-71 |
Sentence |
denotes |
Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6. |
| T1 |
0-71 |
Sentence |
denotes |
Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6. |
| T1 |
0-71 |
Sentence |
denotes |
Galectin-3 promotes HIV-1 budding via association with Alix and Gag p6. |
| TextSentencer_T2 |
72-160 |
Sentence |
denotes |
Galectin-3 has been reported to regulate the functions of a number of immune cell types. |
| T2 |
72-160 |
Sentence |
denotes |
Galectin-3 has been reported to regulate the functions of a number of immune cell types. |
| T2 |
72-160 |
Sentence |
denotes |
Galectin-3 has been reported to regulate the functions of a number of immune cell types. |
| TextSentencer_T3 |
161-346 |
Sentence |
denotes |
We previously reported that galectin-3 is translocated to immunological synapses in T cells upon T-cell receptor engagement, where it associates with ALG-2-interacting protein X (Alix). |
| T3 |
161-346 |
Sentence |
denotes |
We previously reported that galectin-3 is translocated to immunological synapses in T cells upon T-cell receptor engagement, where it associates with ALG-2-interacting protein X (Alix). |
| T3 |
161-346 |
Sentence |
denotes |
We previously reported that galectin-3 is translocated to immunological synapses in T cells upon T-cell receptor engagement, where it associates with ALG-2-interacting protein X (Alix). |
| TextSentencer_T4 |
347-504 |
Sentence |
denotes |
Alix is known to coordinate with the endosomal sorting complex required for transport (ESCRT) to promote human immunodeficiency virus (HIV)-1 virion release. |
| T4 |
347-504 |
Sentence |
denotes |
Alix is known to coordinate with the endosomal sorting complex required for transport (ESCRT) to promote human immunodeficiency virus (HIV)-1 virion release. |
| T4 |
347-504 |
Sentence |
denotes |
Alix is known to coordinate with the endosomal sorting complex required for transport (ESCRT) to promote human immunodeficiency virus (HIV)-1 virion release. |
| TextSentencer_T5 |
505-573 |
Sentence |
denotes |
We hypothesized that galectin-3 plays a role in HIV-1 viral budding. |
| T5 |
505-573 |
Sentence |
denotes |
We hypothesized that galectin-3 plays a role in HIV-1 viral budding. |
| T5 |
505-573 |
Sentence |
denotes |
We hypothesized that galectin-3 plays a role in HIV-1 viral budding. |
| TextSentencer_T6 |
574-803 |
Sentence |
denotes |
Cotransfection of cells of the Jurkat T line with galectin-3 and HIV-1 plasmids resulted in increased HIV-1 budding, and suppression of galectin-3 expression by RNAi in Hut78 and primary CD4+ T cells led to reduced HIV-1 budding. |
| T6 |
574-803 |
Sentence |
denotes |
Cotransfection of cells of the Jurkat T line with galectin-3 and HIV-1 plasmids resulted in increased HIV-1 budding, and suppression of galectin-3 expression by RNAi in Hut78 and primary CD4+ T cells led to reduced HIV-1 budding. |
| T6 |
574-803 |
Sentence |
denotes |
Cotransfection of cells of the Jurkat T line with galectin-3 and HIV-1 plasmids resulted in increased HIV-1 budding, and suppression of galectin-3 expression by RNAi in Hut78 and primary CD4+ T cells led to reduced HIV-1 budding. |
| TextSentencer_T7 |
804-932 |
Sentence |
denotes |
We used immunofluorescence microscopy to observe the partial colocalization of galectin-3, Alix and Gag in HIV-1-infected cells. |
| T7 |
804-932 |
Sentence |
denotes |
We used immunofluorescence microscopy to observe the partial colocalization of galectin-3, Alix and Gag in HIV-1-infected cells. |
| T7 |
804-932 |
Sentence |
denotes |
We used immunofluorescence microscopy to observe the partial colocalization of galectin-3, Alix and Gag in HIV-1-infected cells. |
| TextSentencer_T8 |
933-1149 |
Sentence |
denotes |
Results from co-immunoprecipitation experiments indicate that galectin-3 expression promotes Alix-Gag p6 association, whereas the results of Alix knockdown suggest that galectin-3 promotes HIV-1 budding through Alix. |
| T8 |
933-1149 |
Sentence |
denotes |
Results from co-immunoprecipitation experiments indicate that galectin-3 expression promotes Alix-Gag p6 association, whereas the results of Alix knockdown suggest that galectin-3 promotes HIV-1 budding through Alix. |
| T8 |
933-1320 |
Sentence |
denotes |
Results from co-immunoprecipitation experiments indicate that galectin-3 expression promotes Alix-Gag p6 association, whereas the results of Alix knockdown suggest that galectin-3 promotes HIV-1 budding through Alix. HIV-1 particles released from galectin-3-expressing cells acquire the galectin-3 protein in an Alix-dependent manner, with proteins primarily residing inside the virions. |
| TextSentencer_T9 |
1150-1320 |
Sentence |
denotes |
HIV-1 particles released from galectin-3-expressing cells acquire the galectin-3 protein in an Alix-dependent manner, with proteins primarily residing inside the virions. |
| T9 |
1150-1320 |
Sentence |
denotes |
HIV-1 particles released from galectin-3-expressing cells acquire the galectin-3 protein in an Alix-dependent manner, with proteins primarily residing inside the virions. |
| TextSentencer_T10 |
1321-1420 |
Sentence |
denotes |
We also found that the galectin-3 N-terminal domain interacts with the proline-rich region of Alix. |
| T10 |
1321-1420 |
Sentence |
denotes |
We also found that the galectin-3 N-terminal domain interacts with the proline-rich region of Alix. |
| T9 |
1321-1551 |
Sentence |
denotes |
We also found that the galectin-3 N-terminal domain interacts with the proline-rich region of Alix. Collectively, these results suggest that endogenous galectin-3 facilitates HIV-1 budding by promoting the Alix-Gag p6 association. |
| TextSentencer_T11 |
1421-1551 |
Sentence |
denotes |
Collectively, these results suggest that endogenous galectin-3 facilitates HIV-1 budding by promoting the Alix-Gag p6 association. |
| T11 |
1421-1551 |
Sentence |
denotes |
Collectively, these results suggest that endogenous galectin-3 facilitates HIV-1 budding by promoting the Alix-Gag p6 association. |