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PubMed:24719110 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-101 Sentence denotes Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity.
T1 0-101 Sentence denotes Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity.
TextSentencer_T2 102-286 Sentence denotes This study aims to identify the inhibitory role of the spinal glucagon like peptide-1 receptor (GLP-1R) signaling in pain hypersensitivity and its mechanism of action in rats and mice.
T2 102-286 Sentence denotes This study aims to identify the inhibitory role of the spinal glucagon like peptide-1 receptor (GLP-1R) signaling in pain hypersensitivity and its mechanism of action in rats and mice.
TextSentencer_T3 287-451 Sentence denotes First, GLP-1Rs were identified to be specifically expressed on microglial cells in the spinal dorsal horn, and profoundly upregulated after peripheral nerve injury.
T3 287-451 Sentence denotes First, GLP-1Rs were identified to be specifically expressed on microglial cells in the spinal dorsal horn, and profoundly upregulated after peripheral nerve injury.
TextSentencer_T4 452-692 Sentence denotes In addition, intrathecal GLP-1R agonists GLP-1(7-36) and exenatide potently alleviated formalin-, peripheral nerve injury-, bone cancer-, and diabetes-induced hypersensitivity states by 60-90%, without affecting acute nociceptive responses.
T4 452-692 Sentence denotes In addition, intrathecal GLP-1R agonists GLP-1(7-36) and exenatide potently alleviated formalin-, peripheral nerve injury-, bone cancer-, and diabetes-induced hypersensitivity states by 60-90%, without affecting acute nociceptive responses.
TextSentencer_T5 693-820 Sentence denotes The antihypersensitive effects of exenatide and GLP-1 were completely prevented by GLP-1R antagonism and GLP-1R gene knockdown.
T5 693-820 Sentence denotes The antihypersensitive effects of exenatide and GLP-1 were completely prevented by GLP-1R antagonism and GLP-1R gene knockdown.
TextSentencer_T6 821-920 Sentence denotes Furthermore, exenatide evoked β-endorphin release from both the spinal cord and cultured microglia.
T6 821-920 Sentence denotes Furthermore, exenatide evoked β-endorphin release from both the spinal cord and cultured microglia.
TextSentencer_T7 921-1074 Sentence denotes Exenatide antiallodynia was completely prevented by the microglial inhibitor minocycline, β-endorphin antiserum, and opioid receptor antagonist naloxone.
T7 921-1074 Sentence denotes Exenatide antiallodynia was completely prevented by the microglial inhibitor minocycline, β-endorphin antiserum, and opioid receptor antagonist naloxone.
TextSentencer_T8 1075-1219 Sentence denotes Our results illustrate a novel spinal dorsal horn microglial GLP-1R/β-endorphin inhibitory pathway in a variety of pain hypersensitivity states.
T8 1075-1219 Sentence denotes Our results illustrate a novel spinal dorsal horn microglial GLP-1R/β-endorphin inhibitory pathway in a variety of pain hypersensitivity states.