> top > projects > sentences > docs > PubMed:24603724 > annotations
sentences Home  

PubMed:24603724 JSONTXT 15 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-146 Sentence denotes TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI.
T1 0-146 Sentence denotes TL-118 and gemcitabine drug combination display therapeutic efficacy in a MYCN amplified orthotopic neuroblastoma murine model--evaluation by MRI.
TextSentencer_T2 147-325 Sentence denotes Neuroblastoma (NB) is the most common extra-cranial pediatric solid tumor with up to 50% of NB patients classified as having high-risk disease with poor long-term survival rates.
T2 147-325 Sentence denotes Neuroblastoma (NB) is the most common extra-cranial pediatric solid tumor with up to 50% of NB patients classified as having high-risk disease with poor long-term survival rates.
TextSentencer_T3 326-536 Sentence denotes The poor clinical outcome and aggressiveness of high-risk NB strongly correlates with enhanced angiogenesis, suggesting anti-angiogenic agents as attractive additions to the currently insufficient therapeutics.
T3 326-536 Sentence denotes The poor clinical outcome and aggressiveness of high-risk NB strongly correlates with enhanced angiogenesis, suggesting anti-angiogenic agents as attractive additions to the currently insufficient therapeutics.
TextSentencer_T4 537-628 Sentence denotes TL-118, a novel drug combination has been recently developed to inhibit tumor angiogenesis.
T4 537-628 Sentence denotes TL-118, a novel drug combination has been recently developed to inhibit tumor angiogenesis.
TextSentencer_T5 629-857 Sentence denotes In the current study, we used the SK-N-BE (2) cell line to generate orthotopic NB tumors in order to study the combinational therapeutic potential of TL-118 with either Gemcitabine (40 mg/kg; IP) or Retinoic acid (40 mg/kg; IP).
T5 629-857 Sentence denotes In the current study, we used the SK-N-BE (2) cell line to generate orthotopic NB tumors in order to study the combinational therapeutic potential of TL-118 with either Gemcitabine (40 mg/kg; IP) or Retinoic acid (40 mg/kg; IP).
TextSentencer_T6 858-1010 Sentence denotes We show that TL-118 treatment (n = 9) significantly inhibited tumor growth, increased cell apoptosis, reduced proliferation and extended mouse survival.
T6 858-1010 Sentence denotes We show that TL-118 treatment (n = 9) significantly inhibited tumor growth, increased cell apoptosis, reduced proliferation and extended mouse survival.
TextSentencer_T7 1011-1130 Sentence denotes Moreover, the reciprocal effect of TL-118 and Gemcitabine treatment (n = 10) demonstrated improved anti-tumor activity.
T7 1011-1130 Sentence denotes Moreover, the reciprocal effect of TL-118 and Gemcitabine treatment (n = 10) demonstrated improved anti-tumor activity.
TextSentencer_T8 1131-1390 Sentence denotes The synergistic effect of these drugs in combination was more effective than either TL or Gemcitabine alone (n = 9), via significantly reduced cell proliferation (p<0.005), increased apoptosis (p<0.05) and significantly prolonged survival (2-fold; p<0.00001).
T8 1131-1390 Sentence denotes The synergistic effect of these drugs in combination was more effective than either TL or Gemcitabine alone (n = 9), via significantly reduced cell proliferation (p<0.005), increased apoptosis (p<0.05) and significantly prolonged survival (2-fold; p<0.00001).
TextSentencer_T9 1391-1523 Sentence denotes To conclude, we demonstrate that the novel drug combination TL-118 has the ability to suppress the growth of an aggressive NB tumor.
T9 1391-1523 Sentence denotes To conclude, we demonstrate that the novel drug combination TL-118 has the ability to suppress the growth of an aggressive NB tumor.
TextSentencer_T10 1524-1677 Sentence denotes The promising results with TL-118 in this aggressive animal model may imply that this drug combination has therapeutic potential in the clinical setting.
T10 1524-1677 Sentence denotes The promising results with TL-118 in this aggressive animal model may imply that this drug combination has therapeutic potential in the clinical setting.