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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-80 Sentence denotes Systemic GLIPR1-ΔTM protein as a novel therapeutic approach for prostate cancer.
T1 0-80 Sentence denotes Systemic GLIPR1-ΔTM protein as a novel therapeutic approach for prostate cancer.
TextSentencer_T2 81-356 Sentence denotes GLIPR1 is a p53 target gene known to be downregulated in prostate cancer, and increased endogenous GLIPR1 expression has been associated with increased production of reactive oxygen species, increased apoptosis, decreased c-Myc protein levels and increased cell cycle arrest.
T2 81-356 Sentence denotes GLIPR1 is a p53 target gene known to be downregulated in prostate cancer, and increased endogenous GLIPR1 expression has been associated with increased production of reactive oxygen species, increased apoptosis, decreased c-Myc protein levels and increased cell cycle arrest.
TextSentencer_T3 357-569 Sentence denotes Recently, we found that upregulation of GLIPR1 in prostate cancer cells increases mitotic catastrophe through interaction with heat shock cognate protein 70 (Hsc70) and downregulation of Aurora kinase A and TPX2.
T3 357-569 Sentence denotes Recently, we found that upregulation of GLIPR1 in prostate cancer cells increases mitotic catastrophe through interaction with heat shock cognate protein 70 (Hsc70) and downregulation of Aurora kinase A and TPX2.
TextSentencer_T4 570-855 Sentence denotes In this study, we evaluated the mechanisms of recombinant GLIPR1 protein (glioma pathogenesis-related protein 1-transmembrane domain deleted [GLIPR1-ΔTM]) uptake by prostate cancer cells and the efficacy of systemic GLIPR1-ΔTM administration in a prostate cancer xenograft mouse model.
T4 570-855 Sentence denotes In this study, we evaluated the mechanisms of recombinant GLIPR1 protein (glioma pathogenesis-related protein 1-transmembrane domain deleted [GLIPR1-ΔTM]) uptake by prostate cancer cells and the efficacy of systemic GLIPR1-ΔTM administration in a prostate cancer xenograft mouse model.
TextSentencer_T5 856-1034 Sentence denotes GLIPR1-ΔTM was selectively internalized by prostate cancer cells, leading to increased apoptosis through reactive oxygen species production and to decreased c-Myc protein levels.
T5 856-1034 Sentence denotes GLIPR1-ΔTM was selectively internalized by prostate cancer cells, leading to increased apoptosis through reactive oxygen species production and to decreased c-Myc protein levels.
TextSentencer_T6 1035-1142 Sentence denotes Interestingly, GLIPR1-ΔTM was internalized through clathrin-mediated endocytosis in association with Hsc70.
T6 1035-1142 Sentence denotes Interestingly, GLIPR1-ΔTM was internalized through clathrin-mediated endocytosis in association with Hsc70.
TextSentencer_T7 1143-1227 Sentence denotes Systemic administration of GLIPR1-ΔTM significantly inhibited VCaP xenograft growth.
T7 1143-1227 Sentence denotes Systemic administration of GLIPR1-ΔTM significantly inhibited VCaP xenograft growth.
TextSentencer_T8 1228-1331 Sentence denotes GLIPR1-ΔTM showed no evidence of toxicity following elimination from mouse models 8 hr after injection.
T8 1228-1331 Sentence denotes GLIPR1-ΔTM showed no evidence of toxicity following elimination from mouse models 8 hr after injection.
TextSentencer_T9 1332-1603 Sentence denotes Our results demonstrate that GLIPR1-ΔTM is selectively endocytosed by prostate cancer cells, leading to increased reactive oxygen species production and apoptosis, and that systemic GLIPR1-ΔTM significantly inhibits growth of VCaP xenografts without substantial toxicity.
T9 1332-1603 Sentence denotes Our results demonstrate that GLIPR1-ΔTM is selectively endocytosed by prostate cancer cells, leading to increased reactive oxygen species production and apoptosis, and that systemic GLIPR1-ΔTM significantly inhibits growth of VCaP xenografts without substantial toxicity.