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PubMed:24583847 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-116 Sentence denotes Activation of VCAM-1 and its associated molecule CD44 leads to increased malignant potential of breast cancer cells.
T1 0-116 Sentence denotes Activation of VCAM-1 and its associated molecule CD44 leads to increased malignant potential of breast cancer cells.
TextSentencer_T2 117-324 Sentence denotes VCAM-1 (CD106), a transmembrane glycoprotein, was first reported to play an important role in leukocyte adhesion, leukocyte transendothelial migration and cell activation by binding to integrin VLA-1 (α4β1).
T2 117-324 Sentence denotes VCAM-1 (CD106), a transmembrane glycoprotein, was first reported to play an important role in leukocyte adhesion, leukocyte transendothelial migration and cell activation by binding to integrin VLA-1 (α4β1).
TextSentencer_T3 325-554 Sentence denotes In the present study, we observed that VCAM-1 expression can be induced in many breast cancer epithelial cells by cytokine stimulation in vitro and its up-regulation directly correlated with advanced clinical breast cancer stage.
T3 325-554 Sentence denotes In the present study, we observed that VCAM-1 expression can be induced in many breast cancer epithelial cells by cytokine stimulation in vitro and its up-regulation directly correlated with advanced clinical breast cancer stage.
TextSentencer_T4 555-792 Sentence denotes We found that VCAM-1 over-expression in the NMuMG breast epithelial cells controls the epithelial and mesenchymal transition (EMT) program to increase cell motility rates and promote chemoresistance to doxorubicin and cisplatin in vitro.
T4 555-792 Sentence denotes We found that VCAM-1 over-expression in the NMuMG breast epithelial cells controls the epithelial and mesenchymal transition (EMT) program to increase cell motility rates and promote chemoresistance to doxorubicin and cisplatin in vitro.
TextSentencer_T5 793-1040 Sentence denotes Conversely, in the established MDAMB231 metastatic breast cancer cell line, we confirmed that knockdown of endogenous VCAM-1 expression reduced cell proliferation and inhibited TGFβ1 or IL-6 mediated cell migration, and increased chemosensitivity.
T5 793-1040 Sentence denotes Conversely, in the established MDAMB231 metastatic breast cancer cell line, we confirmed that knockdown of endogenous VCAM-1 expression reduced cell proliferation and inhibited TGFβ1 or IL-6 mediated cell migration, and increased chemosensitivity.
TextSentencer_T6 1041-1191 Sentence denotes Furthermore, we demonstrated that knockdown of endogenous VCAM-1 expression in MDAMB231 cells reduced tumor formation in a SCID xenograft mouse model.
T6 1041-1191 Sentence denotes Furthermore, we demonstrated that knockdown of endogenous VCAM-1 expression in MDAMB231 cells reduced tumor formation in a SCID xenograft mouse model.
TextSentencer_T7 1192-1300 Sentence denotes Signaling studies showed that VCAM-1 physically associates with CD44 and enhances CD44 and ABCG2 expression.
T7 1192-1300 Sentence denotes Signaling studies showed that VCAM-1 physically associates with CD44 and enhances CD44 and ABCG2 expression.
TextSentencer_T8 1301-1495 Sentence denotes Our findings uncover the possible mechanism of VCAM-1 activation facilitating breast cancer progression, and suggest that targeting VCAM-1 is an attractive strategy for therapeutic intervention.
T8 1301-1495 Sentence denotes Our findings uncover the possible mechanism of VCAM-1 activation facilitating breast cancer progression, and suggest that targeting VCAM-1 is an attractive strategy for therapeutic intervention.