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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-133 Sentence denotes Altered dynamics in the circadian oscillation of clock genes in dermal fibroblasts of patients suffering from idiopathic hypersomnia.
T1 0-133 Sentence denotes Altered dynamics in the circadian oscillation of clock genes in dermal fibroblasts of patients suffering from idiopathic hypersomnia.
TextSentencer_T2 134-361 Sentence denotes From single cell organisms to the most complex life forms, the 24-hour circadian rhythm is important for numerous aspects of physiology and behavior such as daily periodic fluctuations in body temperature and sleep-wake cycles.
T2 134-361 Sentence denotes From single cell organisms to the most complex life forms, the 24-hour circadian rhythm is important for numerous aspects of physiology and behavior such as daily periodic fluctuations in body temperature and sleep-wake cycles.
TextSentencer_T3 362-582 Sentence denotes Influenced by environmental cues - mainly by light input -, the central pacemaker in the thalamic suprachiasmatic nuclei (SCN) controls and regulates the internal clock mechanisms which are present in peripheral tissues.
T3 362-582 Sentence denotes Influenced by environmental cues - mainly by light input -, the central pacemaker in the thalamic suprachiasmatic nuclei (SCN) controls and regulates the internal clock mechanisms which are present in peripheral tissues.
TextSentencer_T4 583-910 Sentence denotes In order to correlate modifications in the molecular mechanisms of circadian rhythm with the pathophysiology of idiopathic hypersomnia, this study aimed to investigate the dynamics of the expression of circadian clock genes in dermal fibroblasts of idiopathic hypersomniacs (IH) in comparison to those of healthy controls (HC).
T4 583-910 Sentence denotes In order to correlate modifications in the molecular mechanisms of circadian rhythm with the pathophysiology of idiopathic hypersomnia, this study aimed to investigate the dynamics of the expression of circadian clock genes in dermal fibroblasts of idiopathic hypersomniacs (IH) in comparison to those of healthy controls (HC).
TextSentencer_T5 911-1062 Sentence denotes Ten clinically and polysomnographically proven IH patients were recruited from the department of sleep medicine of the University Hospital of Muenster.
T5 911-1062 Sentence denotes Ten clinically and polysomnographically proven IH patients were recruited from the department of sleep medicine of the University Hospital of Muenster.
TextSentencer_T6 1063-1173 Sentence denotes Clinical diagnosis was done by two consecutive polysomnographies (PSG) and Multiple Sleep Latency Test (MSLT).
T6 1063-1173 Sentence denotes Clinical diagnosis was done by two consecutive polysomnographies (PSG) and Multiple Sleep Latency Test (MSLT).
TextSentencer_T7 1174-1235 Sentence denotes Fourteen clinical healthy volunteers served as control group.
T7 1174-1235 Sentence denotes Fourteen clinical healthy volunteers served as control group.
TextSentencer_T8 1236-1312 Sentence denotes Dermal fibroblasts were obtained via punch biopsy and grown in cell culture.
T8 1236-1312 Sentence denotes Dermal fibroblasts were obtained via punch biopsy and grown in cell culture.
TextSentencer_T9 1313-1541 Sentence denotes The expression of circadian clock genes was investigated by semiquantitative Reverse Transcriptase-PCR qRT-PCR analysis, confirming periodical oscillation of expression of the core circadian clock genes BMAL1, PER1/2 and CRY1/2.
T9 1313-1541 Sentence denotes The expression of circadian clock genes was investigated by semiquantitative Reverse Transcriptase-PCR qRT-PCR analysis, confirming periodical oscillation of expression of the core circadian clock genes BMAL1, PER1/2 and CRY1/2.
TextSentencer_T10 1542-1812 Sentence denotes The amplitude of the rhythmically expressed BMAL1, PER1 and PER2 was significantly dampened in dermal fibroblasts of IH compared to HC over two circadian periods whereas the overall expression of only the key transcriptional factor BMAL1 was significantly reduced in IH.
T10 1542-1812 Sentence denotes The amplitude of the rhythmically expressed BMAL1, PER1 and PER2 was significantly dampened in dermal fibroblasts of IH compared to HC over two circadian periods whereas the overall expression of only the key transcriptional factor BMAL1 was significantly reduced in IH.
TextSentencer_T11 1813-1901 Sentence denotes Our study suggests for the first time an aberrant dynamics in the circadian clock in IH.
T11 1813-1901 Sentence denotes Our study suggests for the first time an aberrant dynamics in the circadian clock in IH.
TextSentencer_T12 1902-2024 Sentence denotes These findings may serve to better understand some clinical features of the pathophysiology in sleep - wake rhythms in IH.
T12 1902-2024 Sentence denotes These findings may serve to better understand some clinical features of the pathophysiology in sleep - wake rhythms in IH.