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PubMed:24381275 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-123 Sentence denotes LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia.
T1 0-123 Sentence denotes LMO4 is essential for paraventricular hypothalamic neuronal activity and calcium channel expression to prevent hyperphagia.
TextSentencer_T2 124-272 Sentence denotes The dramatic increase in the prevalence of obesity reflects a lack of progress in combating one of the most serious health problems of this century.
T2 124-272 Sentence denotes The dramatic increase in the prevalence of obesity reflects a lack of progress in combating one of the most serious health problems of this century.
TextSentencer_T3 273-469 Sentence denotes Recent studies have improved our understanding of the appetitive network by focusing on the paraventricular hypothalamus (PVH), a key region responsible for the homeostatic balance of food intake.
T3 273-469 Sentence denotes Recent studies have improved our understanding of the appetitive network by focusing on the paraventricular hypothalamus (PVH), a key region responsible for the homeostatic balance of food intake.
TextSentencer_T4 470-652 Sentence denotes Here we show that mice with PVH-specific ablation of LIM domain only 4 (Lmo4) become rapidly obese when fed regular chow due to hyperphagia rather than to reduced energy expenditure.
T4 470-652 Sentence denotes Here we show that mice with PVH-specific ablation of LIM domain only 4 (Lmo4) become rapidly obese when fed regular chow due to hyperphagia rather than to reduced energy expenditure.
TextSentencer_T5 653-804 Sentence denotes Brain slice recording of LMO4-deficient PVH neurons showed reduced basal cellular excitability together with reduced voltage-activated Ca(2+) currents.
T5 653-804 Sentence denotes Brain slice recording of LMO4-deficient PVH neurons showed reduced basal cellular excitability together with reduced voltage-activated Ca(2+) currents.
TextSentencer_T6 805-952 Sentence denotes Real-time PCR quantification revealed that LMO4 regulates the expression of Ca(2+) channels (Cacna1h, Cacna1e) that underlie neuronal excitability.
T6 805-952 Sentence denotes Real-time PCR quantification revealed that LMO4 regulates the expression of Ca(2+) channels (Cacna1h, Cacna1e) that underlie neuronal excitability.
TextSentencer_T7 953-1128 Sentence denotes By increasing neuronal activity using designer receptors exclusively activated by designer drugs technology, we could suppress food intake of PVH-specific LMO4-deficient mice.
T7 953-1128 Sentence denotes By increasing neuronal activity using designer receptors exclusively activated by designer drugs technology, we could suppress food intake of PVH-specific LMO4-deficient mice.
TextSentencer_T8 1129-1249 Sentence denotes Together, these results demonstrate that reduced neural activity in LMO4-deficient PVH neurons accounts for hyperphagia.
T8 1129-1249 Sentence denotes Together, these results demonstrate that reduced neural activity in LMO4-deficient PVH neurons accounts for hyperphagia.
TextSentencer_T9 1250-1333 Sentence denotes Thus, maintaining PVH activity is important to prevent hyperphagia-induced obesity.
T9 1250-1333 Sentence denotes Thus, maintaining PVH activity is important to prevent hyperphagia-induced obesity.