| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-142 |
Sentence |
denotes |
Structure-function relationship and evolutionary history of the human selenoprotein M (SelM) found over-expressed in hepatocellular carcinoma. |
| T1 |
0-142 |
Sentence |
denotes |
Structure-function relationship and evolutionary history of the human selenoprotein M (SelM) found over-expressed in hepatocellular carcinoma. |
| TextSentencer_T2 |
143-289 |
Sentence |
denotes |
In humans we know 25 selenoproteins that play important roles in redox regulation, detoxification, immune-system protection and viral suppression. |
| T2 |
143-289 |
Sentence |
denotes |
In humans we know 25 selenoproteins that play important roles in redox regulation, detoxification, immune-system protection and viral suppression. |
| TextSentencer_T3 |
290-473 |
Sentence |
denotes |
In particular, selenoprotein M (SelM) may function as thiol disulfide oxidoreductase that participates in the formation of disulfide bonds, and can be implicated in calcium responses. |
| T3 |
290-473 |
Sentence |
denotes |
In particular, selenoprotein M (SelM) may function as thiol disulfide oxidoreductase that participates in the formation of disulfide bonds, and can be implicated in calcium responses. |
| TextSentencer_T4 |
474-688 |
Sentence |
denotes |
However, it presents a redox motif (CXXU), where U is a selenocysteine, and may also function as redox regulator because its decreased or increased expression regulated by dietary selenium alters redox homeostasis. |
| T4 |
474-688 |
Sentence |
denotes |
However, it presents a redox motif (CXXU), where U is a selenocysteine, and may also function as redox regulator because its decreased or increased expression regulated by dietary selenium alters redox homeostasis. |
| TextSentencer_T5 |
689-795 |
Sentence |
denotes |
No data are reported in literature about its involvement in cancer but only in neurodegenerative diseases. |
| T5 |
689-795 |
Sentence |
denotes |
No data are reported in literature about its involvement in cancer but only in neurodegenerative diseases. |
| TextSentencer_T6 |
796-918 |
Sentence |
denotes |
In this paper we evaluated the SelM expression in two hepatoma cell lines, HepG2 and Huh7, compared to normal hepatocytes. |
| T6 |
796-918 |
Sentence |
denotes |
In this paper we evaluated the SelM expression in two hepatoma cell lines, HepG2 and Huh7, compared to normal hepatocytes. |
| TextSentencer_T7 |
919-1079 |
Sentence |
denotes |
The results suggested its involvement in hepatocellular carcinoma (HCC) as well as its possible use to follow the progression of this cancer as putative marker. |
| T7 |
919-1079 |
Sentence |
denotes |
The results suggested its involvement in hepatocellular carcinoma (HCC) as well as its possible use to follow the progression of this cancer as putative marker. |
| TextSentencer_T8 |
1080-1167 |
Sentence |
denotes |
The aim of this study has been to analyze the structure-function relationships of SelM. |
| T8 |
1080-1167 |
Sentence |
denotes |
The aim of this study has been to analyze the structure-function relationships of SelM. |
| TextSentencer_T9 |
1168-1305 |
Sentence |
denotes |
Hence, firstly we studied the evolutionary history of this protein by phylogenetic analysis and GC content of genes from various species. |
| T9 |
1168-1305 |
Sentence |
denotes |
Hence, firstly we studied the evolutionary history of this protein by phylogenetic analysis and GC content of genes from various species. |
| TextSentencer_T10 |
1306-1440 |
Sentence |
denotes |
So, we modeled the three-dimensional structure of the human SelM evaluating its energetic stability by molecular dynamics simulations. |
| T10 |
1306-1440 |
Sentence |
denotes |
So, we modeled the three-dimensional structure of the human SelM evaluating its energetic stability by molecular dynamics simulations. |
| TextSentencer_T11 |
1441-1555 |
Sentence |
denotes |
Moreover, we modeled some of its mutants to obtain structural information helpful for structure-based drug design. |
| T11 |
1441-1555 |
Sentence |
denotes |
Moreover, we modeled some of its mutants to obtain structural information helpful for structure-based drug design. |
