| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-100 |
Sentence |
denotes |
Characterization of a stem-like subpopulation in basal-like ductal carcinoma in situ (DCIS) lesions. |
| T2 |
101-202 |
Sentence |
denotes |
Previously, we found that basal-like ductal carcinoma in situ (DCIS) contains cancer stem-like cells. |
| T3 |
203-387 |
Sentence |
denotes |
Here, we characterize stem-like subpopulations in a model of basal-like DCIS and identify subpopulations of CD49f+/CD24- stem-like cells that possess aldehyde dehydrogenase 1 activity. |
| T4 |
388-482 |
Sentence |
denotes |
We found that these cells show enhanced migration potential compared with non-stem DCIS cells. |
| T5 |
483-689 |
Sentence |
denotes |
We also found that the chemopreventive agent sulforaphane can target these DCIS stem-like cells, reduce aldehyde dehydrogenase 1 (ALDH1) expression, and decrease mammosphere and progenitor colony formation. |
| T6 |
690-908 |
Sentence |
denotes |
Furthermore, we characterized exosomal trafficking of microRNAs in DCIS and found that several microRNAs (miRs) including miR-140, miR-29a, and miR-21 are differentially expressed in exosomes from DCIS stem-like cells. |
| T7 |
909-1086 |
Sentence |
denotes |
We found that SFN treatment could reprogram DCIS stem-like cells as evidenced by significant changes in exosomal secretion more closely resembling that of non-stem cancer cells. |
| T8 |
1087-1200 |
Sentence |
denotes |
Finally, we demonstrated that exosomal secretion of miR-140 might impact signaling in nearby breast cancer cells. |
