| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-64 |
Sentence |
denotes |
O-GlcNAcylation of cofilin promotes breast cancer cell invasion. |
| T2 |
65-250 |
Sentence |
denotes |
O-GlcNAcylation is a post-translational modification that regulates a broad range of nuclear and cytoplasmic proteins and is emerging as a key regulator of various biological processes. |
| T3 |
251-482 |
Sentence |
denotes |
Previous studies have shown that increased levels of global O-GlcNAcylation and O-GlcNAc transferase (OGT) are linked to the incidence of metastasis in breast cancer patients, but the molecular basis behind this is not fully known. |
| T4 |
483-653 |
Sentence |
denotes |
In this study, we have determined that the actin-binding protein cofilin is O-GlcNAcylated by OGT and mainly, if not completely, mediates OGT modulation of cell mobility. |
| T5 |
654-829 |
Sentence |
denotes |
O-GlcNAcylation at Ser-108 of cofilin is required for its proper localization in invadopodia at the leading edge of breast cancer cells during three-dimensional cell invasion. |
| T6 |
830-1015 |
Sentence |
denotes |
Loss of O-GlcNAcylation of cofilin leads to destabilization of invadopodia and impairs cell invasion, although the actin-severing activity or lamellipodial localization is not affected. |
| T7 |
1016-1209 |
Sentence |
denotes |
Our study provides insights into the mechanism of post-translational modification in fine-tuning the regulation of cofilin activity and suggests its important implications in cancer metastasis. |
