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PubMed:24164897 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-170 Sentence denotes Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells.
T1 0-170 Sentence denotes Temporal production of the signaling lipid phosphatidic acid by phospholipase D2 determines the output of extracellular signal-regulated kinase signaling in cancer cells.
TextSentencer_T2 171-273 Sentence denotes The Ras-extracellular signal-regulated kinase (ERK) cascade is an important signaling module in cells.
T2 171-273 Sentence denotes The Ras-extracellular signal-regulated kinase (ERK) cascade is an important signaling module in cells.
TextSentencer_T3 274-404 Sentence denotes One regulator of the Ras-ERK cascade is phosphatidic acid (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK).
T3 274-404 Sentence denotes One regulator of the Ras-ERK cascade is phosphatidic acid (PA) generated by phospholipase D (PLD) and diacylglycerol kinase (DGK).
TextSentencer_T4 405-636 Sentence denotes Using a newly developed PA biosensor, PASS (phosphatidic acid biosensor with superior sensitivity), we found that PA was generated sequentially by PLD and DGK in epidermal growth factor (EGF)-stimulated HCC1806 breast cancer cells.
T4 405-636 Sentence denotes Using a newly developed PA biosensor, PASS (phosphatidic acid biosensor with superior sensitivity), we found that PA was generated sequentially by PLD and DGK in epidermal growth factor (EGF)-stimulated HCC1806 breast cancer cells.
TextSentencer_T5 637-880 Sentence denotes Inhibition of PLD2, one of the two PLD members, was sufficient to eliminate most of the PA production, whereas inhibition of DGK decreased PA production only at the later stages of EGF stimulation, suggesting that PLD2 precedes DGK activation.
T5 637-880 Sentence denotes Inhibition of PLD2, one of the two PLD members, was sufficient to eliminate most of the PA production, whereas inhibition of DGK decreased PA production only at the later stages of EGF stimulation, suggesting that PLD2 precedes DGK activation.
TextSentencer_T6 881-966 Sentence denotes The temporal production of PA by PLD2 is important for the nuclear activation of ERK.
T6 881-966 Sentence denotes The temporal production of PA by PLD2 is important for the nuclear activation of ERK.
TextSentencer_T7 967-1148 Sentence denotes While inhibition of both PLD and DGK had no effect on the overall ERK activity, inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines.
T7 967-1148 Sentence denotes While inhibition of both PLD and DGK had no effect on the overall ERK activity, inhibition of PLD2 but not PLD1 or DGK blocked the nuclear ERK activity in several cancer cell lines.
TextSentencer_T8 1149-1319 Sentence denotes The decrease of active ERK in the nucleus inhibited the activation of Elk1, c-fos, and Fra1, the ERK nuclear targets, leading to decreased proliferation of HCC1806 cells.
T8 1149-1319 Sentence denotes The decrease of active ERK in the nucleus inhibited the activation of Elk1, c-fos, and Fra1, the ERK nuclear targets, leading to decreased proliferation of HCC1806 cells.
TextSentencer_T9 1320-1447 Sentence denotes Together, these findings reveal that PA production by PLD2 determines the output of ERK in cancer cell growth factor signaling.
T9 1320-1447 Sentence denotes Together, these findings reveal that PA production by PLD2 determines the output of ERK in cancer cell growth factor signaling.