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PubMed:24089523 JSONTXT 23 Projects

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Id Subject Object Predicate Lexical cue
T1 0-132 Sentence denotes Extracellular signal-regulated kinase (ERK) phosphorylates histone deacetylase 6 (HDAC6) at serine 1035 to stimulate cell migration.
T2 133-289 Sentence denotes Histone deacetylase 6 (HDAC6) is well known for its ability to promote cell migration through deacetylation of its cytoplasmic substrates such as α-tubulin.
T3 290-370 Sentence denotes However, how HDAC6 itself is regulated to control cell motility remains elusive.
T4 371-518 Sentence denotes Previous studies have shown that one third of extracellular signal-regulated kinase (ERK) is associated with the microtubule cytoskeleton in cells.
T5 519-580 Sentence denotes Yet, no connection between HDAC6 and ERK has been discovered.
T6 581-717 Sentence denotes Here, for the first time, we reveal that ERK binds to and phosphorylates HDAC6 to promote cell migration via deacetylation of α-tubulin.
T7 718-823 Sentence denotes We have identified two novel ERK-mediated phosphorylation sites: threonine 1031 and serine 1035 in HDAC6.
T8 824-989 Sentence denotes Both sites were phosphorylated by ERK1 in vitro, whereas Ser-1035 was phosphorylated in response to the activation of EGFR-Ras-Raf-MEK-ERK signaling pathway in vivo.
T9 990-1172 Sentence denotes HDAC6-null mouse embryonic fibroblasts rescued by the nonphosphorylation mimicking mutant displayed significantly reduced cell migration compared with those rescued by the wild type.
T10 1173-1306 Sentence denotes Consistently, the nonphosphorylation mimicking mutant exerted lower tubulin deacetylase activity in vivo compared with the wild type.
T11 1307-1403 Sentence denotes These data indicate that ERK/HDAC6-mediated cell motility is through deacetylation of α-tubulin.
T12 1404-1520 Sentence denotes Overall, our results suggest that HDAC6-mediated cell migration could be governed by EGFR-Ras-Raf-MEK-ERK signaling.