| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-132 |
Sentence |
denotes |
The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia. |
| T1 |
0-132 |
Sentence |
denotes |
The BCL2-938 C > A promoter polymorphism is associated with risk group classification in children with acute lymphoblastic leukemia. |
| TextSentencer_T2 |
133-144 |
Sentence |
denotes |
BACKGROUND: |
| T2 |
133-144 |
Sentence |
denotes |
BACKGROUND: |
| TextSentencer_T3 |
145-216 |
Sentence |
denotes |
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. |
| T3 |
145-216 |
Sentence |
denotes |
Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer. |
| TextSentencer_T4 |
217-351 |
Sentence |
denotes |
While current treatment regimens achieve almost 80% overall survival, long-term side effects of chemotherapeutic agents can be severe. |
| T4 |
217-351 |
Sentence |
denotes |
While current treatment regimens achieve almost 80% overall survival, long-term side effects of chemotherapeutic agents can be severe. |
| TextSentencer_T5 |
352-502 |
Sentence |
denotes |
The functional BCL2-938C > A promoter polymorphism is known to influence the balance between survival and apoptosis of malignant hematolymphoid cells. |
| T5 |
352-502 |
Sentence |
denotes |
The functional BCL2-938C > A promoter polymorphism is known to influence the balance between survival and apoptosis of malignant hematolymphoid cells. |
| TextSentencer_T6 |
503-597 |
Sentence |
denotes |
We investigated its usefulness as a marker for treatment stratification for children with ALL. |
| T6 |
503-597 |
Sentence |
denotes |
We investigated its usefulness as a marker for treatment stratification for children with ALL. |
| TextSentencer_T7 |
598-606 |
Sentence |
denotes |
METHODS: |
| T7 |
598-606 |
Sentence |
denotes |
METHODS: |
| TextSentencer_T8 |
607-747 |
Sentence |
denotes |
We analyzed DNA from 182 children suffering from ALL in this study to determine genotypes of the -938 C > A polymorphism by "slow-down" PCR. |
| T8 |
607-747 |
Sentence |
denotes |
We analyzed DNA from 182 children suffering from ALL in this study to determine genotypes of the -938 C > A polymorphism by "slow-down" PCR. |
| TextSentencer_T9 |
748-873 |
Sentence |
denotes |
RESULTS: ALL patients with the BCL2-938CC genotype had an approximately 3-fold higher risk of belonging to a high-risk group. |
| T9 |
748-873 |
Sentence |
denotes |
RESULTS: ALL patients with the BCL2-938CC genotype had an approximately 3-fold higher risk of belonging to a high-risk group. |
| TextSentencer_T10 |
874-1093 |
Sentence |
denotes |
Within the high-risk group, 50% of BCL2-938CC patients were classified as high-risk due to poor prednisone response whereas only 33% of patients with AC and AA genotypes were classified as high-risk for the same reason. |
| T10 |
874-1093 |
Sentence |
denotes |
Within the high-risk group, 50% of BCL2-938CC patients were classified as high-risk due to poor prednisone response whereas only 33% of patients with AC and AA genotypes were classified as high-risk for the same reason. |
| TextSentencer_T11 |
1094-1106 |
Sentence |
denotes |
CONCLUSIONS: |
| T11 |
1094-1106 |
Sentence |
denotes |
CONCLUSIONS: |
| TextSentencer_T12 |
1107-1349 |
Sentence |
denotes |
Our results suggest that BCL2-938C > A genotyping may be beneficial for therapy response prediction in ALL patients, and warrant examination in a larger cohort to validate its usefulness for treatment stratification of pediatric ALL patients. |
| T12 |
1107-1349 |
Sentence |
denotes |
Our results suggest that BCL2-938C > A genotyping may be beneficial for therapy response prediction in ALL patients, and warrant examination in a larger cohort to validate its usefulness for treatment stratification of pediatric ALL patients. |