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PubMed:24085799 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-83 Sentence denotes miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1.
T1 0-83 Sentence denotes miR-720 inhibits tumor invasion and migration in breast cancer by targeting TWIST1.
TextSentencer_T2 84-239 Sentence denotes Breast cancer is the leading cause of cancer death among females, with tumor metastasis being primarily responsible for breast cancer-associated mortality.
T2 84-239 Sentence denotes Breast cancer is the leading cause of cancer death among females, with tumor metastasis being primarily responsible for breast cancer-associated mortality.
TextSentencer_T3 240-330 Sentence denotes Current literatures have shown that microRNAs (miRNAs) are implicated in tumor metastasis.
T3 240-330 Sentence denotes Current literatures have shown that microRNAs (miRNAs) are implicated in tumor metastasis.
TextSentencer_T4 331-493 Sentence denotes In this study, we found that the expression of miR-720 was significantly downregulated in primary breast cancer, with greater downregulation in metastatic tumors.
T4 331-493 Sentence denotes In this study, we found that the expression of miR-720 was significantly downregulated in primary breast cancer, with greater downregulation in metastatic tumors.
TextSentencer_T5 494-651 Sentence denotes Statistical analysis of 105 cases of primary human breast cancer demonstrated that decreased expression of miR-720 was correlated with lymph node metastasis.
T5 494-651 Sentence denotes Statistical analysis of 105 cases of primary human breast cancer demonstrated that decreased expression of miR-720 was correlated with lymph node metastasis.
TextSentencer_T6 652-791 Sentence denotes Furthermore, reexpression of miR-720 in breast cancer cells remarkably inhibited cell invasiveness and migration both in vitro and in vivo.
T6 652-791 Sentence denotes Furthermore, reexpression of miR-720 in breast cancer cells remarkably inhibited cell invasiveness and migration both in vitro and in vivo.
TextSentencer_T7 792-969 Sentence denotes Mechanistically, downregulation of TWIST1, a promoter of metastasis that was identified as a direct functional target of miR-720, was attributed to the inhibition of metastasis.
T7 792-969 Sentence denotes Mechanistically, downregulation of TWIST1, a promoter of metastasis that was identified as a direct functional target of miR-720, was attributed to the inhibition of metastasis.
TextSentencer_T8 970-1217 Sentence denotes Consistent with the reduced TWIST1 levels in breast cancer, reexpression of miR-720 upregulated epithelial markers (E-cadherin and β-catenin) and downregulated mesenchymal markers (N-cadherin, fibronectin, vimentin and matrix metalloproteinase-2).
T8 970-1217 Sentence denotes Consistent with the reduced TWIST1 levels in breast cancer, reexpression of miR-720 upregulated epithelial markers (E-cadherin and β-catenin) and downregulated mesenchymal markers (N-cadherin, fibronectin, vimentin and matrix metalloproteinase-2).
TextSentencer_T9 1218-1308 Sentence denotes Expression of miR-720 was inversely associated with TWIST1 in human breast cancer tissues.
T9 1218-1308 Sentence denotes Expression of miR-720 was inversely associated with TWIST1 in human breast cancer tissues.
TextSentencer_T10 1309-1540 Sentence denotes Knockdown of TWIST1 expression by small interfering RNA exhibited similar effects to reintroduction of miR-720, whereas overexpression of TWIST1 (without the 3'-untranslated region) abrogated miR-720-mediated metastasis inhibition.
T10 1309-1540 Sentence denotes Knockdown of TWIST1 expression by small interfering RNA exhibited similar effects to reintroduction of miR-720, whereas overexpression of TWIST1 (without the 3'-untranslated region) abrogated miR-720-mediated metastasis inhibition.
TextSentencer_T11 1541-1769 Sentence denotes Collectively, our data indicate that miR-720 is frequently decreased in breast cancer and manifests antimetastatic activity by downregulating TWIST1, presenting a novel mechanism of miRNA-mediated regulation of tumor metastasis.
T11 1541-1769 Sentence denotes Collectively, our data indicate that miR-720 is frequently decreased in breast cancer and manifests antimetastatic activity by downregulating TWIST1, presenting a novel mechanism of miRNA-mediated regulation of tumor metastasis.