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Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-137 Sentence denotes Transcription factor C/EBPα-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia.
T1 0-137 Sentence denotes Transcription factor C/EBPα-induced microRNA-30c inactivates Notch1 during granulopoiesis and is downregulated in acute myeloid leukemia.
TextSentencer_T2 138-305 Sentence denotes The transcription factor CCAAT enhancer binding protein α (C/EBPα) is a master regulator in granulopoiesis and is frequently disrupted in acute myeloid leukemia (AML).
T2 138-305 Sentence denotes The transcription factor CCAAT enhancer binding protein α (C/EBPα) is a master regulator in granulopoiesis and is frequently disrupted in acute myeloid leukemia (AML).
TextSentencer_T3 306-421 Sentence denotes We have previously shown that C/EBPα exerts its effects by regulating microRNAs (miRs) such as miR-223 and miR-34a.
T3 306-421 Sentence denotes We have previously shown that C/EBPα exerts its effects by regulating microRNAs (miRs) such as miR-223 and miR-34a.
TextSentencer_T4 422-507 Sentence denotes Here, we confirm miR-30c as a novel important target of C/EBPα during granulopoiesis.
T4 422-507 Sentence denotes Here, we confirm miR-30c as a novel important target of C/EBPα during granulopoiesis.
TextSentencer_T5 508-718 Sentence denotes Thus, wild-type C/EBPα-p42 directly upregulates miR-30c expression, whereas C/EBPα-p30, found in AML, does not. miR-30c is downregulated in AML, especially in normal karyotype AML patients with CEBPA mutations.
T5 508-718 Sentence denotes Thus, wild-type C/EBPα-p42 directly upregulates miR-30c expression, whereas C/EBPα-p30, found in AML, does not. miR-30c is downregulated in AML, especially in normal karyotype AML patients with CEBPA mutations.
TextSentencer_T6 719-835 Sentence denotes An induced C/EBPα knockout in mice leads to a significant downregulation of miR-30c expression in bone marrow cells.
T6 719-835 Sentence denotes An induced C/EBPα knockout in mice leads to a significant downregulation of miR-30c expression in bone marrow cells.
TextSentencer_T7 836-887 Sentence denotes We identified NOTCH1 as a direct target of miR-30c.
T7 836-887 Sentence denotes We identified NOTCH1 as a direct target of miR-30c.
TextSentencer_T8 888-1040 Sentence denotes Finally, a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation.
T8 888-1040 Sentence denotes Finally, a block of miR-30c prevents C/EBPα-induced downregulation of Notch1 protein and leads to a reduced CD11b expression in myeloid differentiation.
TextSentencer_T9 1041-1228 Sentence denotes Our study presents the first evidence that C/EBPα, miR-30c, and Notch1 together play a critical role in granulocytic differentiation and AML, and particularly in AML with CEBPA mutations.
T9 1041-1228 Sentence denotes Our study presents the first evidence that C/EBPα, miR-30c, and Notch1 together play a critical role in granulocytic differentiation and AML, and particularly in AML with CEBPA mutations.
TextSentencer_T10 1229-1370 Sentence denotes These data reveal the importance of deregulated miRNA expression in leukemia and may provide novel biomarkers and therapeutic targets in AML.
T10 1229-1370 Sentence denotes These data reveal the importance of deregulated miRNA expression in leukemia and may provide novel biomarkers and therapeutic targets in AML.