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PubMed:23968733 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-163 Sentence denotes Increased expression of miR-126 and miR-10a predict prolonged relapse-free time of primary oestrogen receptor-positive breast cancer following tamoxifen treatment.
T1 0-163 Sentence denotes Increased expression of miR-126 and miR-10a predict prolonged relapse-free time of primary oestrogen receptor-positive breast cancer following tamoxifen treatment.
TextSentencer_T2 164-175 Sentence denotes BACKGROUND:
T2 164-175 Sentence denotes BACKGROUND:
TextSentencer_T3 176-285 Sentence denotes Adjuvant tamoxifen is a valid treatment option for women with oestrogen receptor (ER)-positive breast cancer.
T3 176-285 Sentence denotes Adjuvant tamoxifen is a valid treatment option for women with oestrogen receptor (ER)-positive breast cancer.
TextSentencer_T4 286-363 Sentence denotes However, up to 40% of patients experience distant or local recurrence or die.
T4 286-363 Sentence denotes However, up to 40% of patients experience distant or local recurrence or die.
TextSentencer_T5 364-443 Sentence denotes MicroRNAs have been suggested to be important prognosticators in breast cancer.
T5 364-443 Sentence denotes MicroRNAs have been suggested to be important prognosticators in breast cancer.
TextSentencer_T6 444-531 Sentence denotes This study aims to identify microRNAs with the potential to predict tamoxifen response.
T6 444-531 Sentence denotes This study aims to identify microRNAs with the potential to predict tamoxifen response.
TextSentencer_T7 532-553 Sentence denotes PATIENTS AND METHODS:
T7 532-553 Sentence denotes PATIENTS AND METHODS:
TextSentencer_T8 554-813 Sentence denotes We performed a global microRNA screen (1105 human microRNAs) in primary tumours of six matched pairs of postmenopausal, ER-positive breast cancer patients treated with tamoxifen, who were either recurrence free or had developed a recurrence (median follow up:
T8 554-813 Sentence denotes We performed a global microRNA screen (1105 human microRNAs) in primary tumours of six matched pairs of postmenopausal, ER-positive breast cancer patients treated with tamoxifen, who were either recurrence free or had developed a recurrence (median follow up:
TextSentencer_T9 814-832 Sentence denotes 8.84 years; range:
T9 814-832 Sentence denotes 8.84 years; range:
TextSentencer_T10 833-850 Sentence denotes 1.28-12.7 years).
T10 833-850 Sentence denotes 1.28-12.7 years).
TextSentencer_T11 851-942 Sentence denotes Patients of this discovery set and the 81 patients of the validation set (median follow up:
T11 851-942 Sentence denotes Patients of this discovery set and the 81 patients of the validation set (median follow up:
TextSentencer_T12 943-961 Sentence denotes 8.64 years; range:
T12 943-961 Sentence denotes 8.64 years; range:
TextSentencer_T13 962-1065 Sentence denotes 0.21-19.85 years) were treated at the Robert Bosch Hospital, Stuttgart, Germany, between 1986 and 2005.
T13 962-1065 Sentence denotes 0.21-19.85 years) were treated at the Robert Bosch Hospital, Stuttgart, Germany, between 1986 and 2005.
TextSentencer_T14 1066-1074 Sentence denotes RESULTS:
T14 1066-1074 Sentence denotes RESULTS:
TextSentencer_T15 1075-1219 Sentence denotes Out of the top 20 deregulated microRNAs (12 up-regulated, eight down-regulated) miR-126 (Hazard Ratio (HR) = 0.56, 95% confidence interval (CI):
T15 1075-1219 Sentence denotes Out of the top 20 deregulated microRNAs (12 up-regulated, eight down-regulated) miR-126 (Hazard Ratio (HR) = 0.56, 95% confidence interval (CI):
TextSentencer_T16 1220-1240 Sentence denotes 0.38-0.83; Holm-adj.
T16 1220-1240 Sentence denotes 0.38-0.83; Holm-adj.
TextSentencer_T17 1241-1283 Sentence denotes P = 0.022) and miR-10a (HR = 0.53, 95% CI:
T17 1241-1283 Sentence denotes P = 0.022) and miR-10a (HR = 0.53, 95% CI:
TextSentencer_T18 1284-1304 Sentence denotes 0.33-0.85; Holm-adj.
T18 1284-1304 Sentence denotes 0.33-0.85; Holm-adj.
TextSentencer_T19 1305-1496 Sentence denotes P = 0.031) were identified as significant predictors of tamoxifen outcome by multivariate Cox regression analysis in the independent validation set of 81 postmenopausal, ER-positive patients.
T19 1305-1496 Sentence denotes P = 0.031) were identified as significant predictors of tamoxifen outcome by multivariate Cox regression analysis in the independent validation set of 81 postmenopausal, ER-positive patients.
TextSentencer_T20 1497-1773 Sentence denotes Kaplan-Meier survival analyses based on cut-offs determined by receiver operating characteristics curves confirmed that a higher expression of miR-126 and miR-10a in the patients tumour was associated with longer relapse-free time (log-rank P = 0.037, P<0.0001, respectively).
T20 1497-1773 Sentence denotes Kaplan-Meier survival analyses based on cut-offs determined by receiver operating characteristics curves confirmed that a higher expression of miR-126 and miR-10a in the patients tumour was associated with longer relapse-free time (log-rank P = 0.037, P<0.0001, respectively).
TextSentencer_T21 1774-1786 Sentence denotes CONCLUSIONS:
T21 1774-1786 Sentence denotes CONCLUSIONS:
TextSentencer_T22 1787-1954 Sentence denotes Our data suggest that miR-126 and miR-10a are independent predictors for tumour relapse in early postmenopausal breast cancer patients treated with adjuvant tamoxifen.
T22 1787-1954 Sentence denotes Our data suggest that miR-126 and miR-10a are independent predictors for tumour relapse in early postmenopausal breast cancer patients treated with adjuvant tamoxifen.