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PubMed:23928928 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-146 Sentence denotes Association between environmental tobacco smoke exposure and lung cancer susceptibility: modification by antioxidant enzyme genetic polymorphisms.
T1 0-146 Sentence denotes Association between environmental tobacco smoke exposure and lung cancer susceptibility: modification by antioxidant enzyme genetic polymorphisms.
TextSentencer_T2 147-158 Sentence denotes BACKGROUND:
T2 147-158 Sentence denotes BACKGROUND:
TextSentencer_T3 159-253 Sentence denotes Environmental tobacco smoke (ETS) is the primary etiologic factor responsible for lung cancer.
T3 159-253 Sentence denotes Environmental tobacco smoke (ETS) is the primary etiologic factor responsible for lung cancer.
TextSentencer_T4 254-388 Sentence denotes However, only 10-15 % of smokers develop lung cancer, suggesting a genetic role in modifying individual susceptibility to lung cancer.
T4 254-388 Sentence denotes However, only 10-15 % of smokers develop lung cancer, suggesting a genetic role in modifying individual susceptibility to lung cancer.
TextSentencer_T5 389-456 Sentence denotes Antioxidant enzymes and genetic polymorphisms should be considered.
T5 389-456 Sentence denotes Antioxidant enzymes and genetic polymorphisms should be considered.
TextSentencer_T6 457-461 Sentence denotes AIM:
T6 457-461 Sentence denotes AIM:
TextSentencer_T7 462-644 Sentence denotes The present study aimed to evaluate the role of antioxidant enzyme activity and genetic polymorphisms in modifying the susceptibility to lung cancer among individuals exposed to ETS.
T7 462-644 Sentence denotes The present study aimed to evaluate the role of antioxidant enzyme activity and genetic polymorphisms in modifying the susceptibility to lung cancer among individuals exposed to ETS.
TextSentencer_T8 645-666 Sentence denotes SUBJECTS AND METHODS:
T8 645-666 Sentence denotes SUBJECTS AND METHODS:
TextSentencer_T9 667-727 Sentence denotes A total of 150 male subjects were divided into three groups:
T9 667-727 Sentence denotes A total of 150 male subjects were divided into three groups:
TextSentencer_T10 728-796 Sentence denotes 50 lung cancer patients, 50 chronic smokers, and 50 passive smokers.
T10 728-796 Sentence denotes 50 lung cancer patients, 50 chronic smokers, and 50 passive smokers.
TextSentencer_T11 797-1002 Sentence denotes Genotyping of microsomal epoxide hydrolase (mEH) exon 3 (Tyr(113)Hist) and exon 4 (Hist(139)Arg) polymorphisms were done by the polymerase chain reaction-restriction fragment length polymorphism technique.
T11 797-1002 Sentence denotes Genotyping of microsomal epoxide hydrolase (mEH) exon 3 (Tyr(113)Hist) and exon 4 (Hist(139)Arg) polymorphisms were done by the polymerase chain reaction-restriction fragment length polymorphism technique.
TextSentencer_T12 1003-1078 Sentence denotes MnSOD (Val(16)Ala) polymorphism was detected by the real time-TaqMan assay.
T12 1003-1078 Sentence denotes MnSOD (Val(16)Ala) polymorphism was detected by the real time-TaqMan assay.
TextSentencer_T13 1079-1142 Sentence denotes Erythrocyte MnSOD activity was measured spectrophotometrically.
T13 1079-1142 Sentence denotes Erythrocyte MnSOD activity was measured spectrophotometrically.
TextSentencer_T14 1143-1329 Sentence denotes RESULTS: ETS-exposed individuals (both active and passive smokers) who carried the His allele of mEH exon3 have a 2.9-fold increased risk of lung cancer (odds ratio [OR] 2.9, P < 0.001).
T14 1143-1329 Sentence denotes RESULTS: ETS-exposed individuals (both active and passive smokers) who carried the His allele of mEH exon3 have a 2.9-fold increased risk of lung cancer (odds ratio [OR] 2.9, P < 0.001).
TextSentencer_T15 1330-1462 Sentence denotes In addition, ETS-exposed carriers of the Arg allele of mEH exon 4 have a 2.1-fold increased risk of lung cancer (OR 2.1, P = 0.024).
T15 1330-1462 Sentence denotes In addition, ETS-exposed carriers of the Arg allele of mEH exon 4 have a 2.1-fold increased risk of lung cancer (OR 2.1, P = 0.024).
TextSentencer_T16 1463-1732 Sentence denotes However, no association between the MnSOD Val(16)Ala polymorphism and lung cancer was detected among ETS-exposed individuals (OR 1.6, P = 0.147), although the lung cancer group had significantly lower MnSOD activity than the chronic or passive smoker groups (P = 0.03).
T16 1463-1732 Sentence denotes However, no association between the MnSOD Val(16)Ala polymorphism and lung cancer was detected among ETS-exposed individuals (OR 1.6, P = 0.147), although the lung cancer group had significantly lower MnSOD activity than the chronic or passive smoker groups (P = 0.03).
TextSentencer_T17 1733-1745 Sentence denotes CONCLUSIONS:
T17 1733-1745 Sentence denotes CONCLUSIONS:
TextSentencer_T18 1746-1873 Sentence denotes Exons 3 and 4 polymorphisms of the mEH gene may contribute to lung cancer susceptibility through disturbed antioxidant balance.
T18 1746-1873 Sentence denotes Exons 3 and 4 polymorphisms of the mEH gene may contribute to lung cancer susceptibility through disturbed antioxidant balance.
TextSentencer_T19 1874-1961 Sentence denotes However, this was not the case with the MnSOD Val(16)Ala single-nucleotid polymorphism.
T19 1874-1961 Sentence denotes However, this was not the case with the MnSOD Val(16)Ala single-nucleotid polymorphism.
TextSentencer_T20 1962-2045 Sentence denotes Antioxidant enzymes may modulate the influence of ETS exposure on lung cancer risk.
T20 1962-2045 Sentence denotes Antioxidant enzymes may modulate the influence of ETS exposure on lung cancer risk.