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PubMed:23913163 JSONTXT 10 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-78 Sentence denotes Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis.
T1 0-78 Sentence denotes Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis.
TextSentencer_T2 79-90 Sentence denotes UNLABELLED:
T2 79-90 Sentence denotes UNLABELLED:
TextSentencer_T3 91-211 Sentence denotes Cadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells.
T3 91-211 Sentence denotes Cadherin-11 (CDH11) is a member of the cadherin superfamily mainly expressed in osteoblasts but not in epithelial cells.
TextSentencer_T4 212-349 Sentence denotes However, prostate cancer cells with a propensity for bone metastasis express high levels of cadherin-11 and reduced levels of E-cadherin.
T4 212-349 Sentence denotes However, prostate cancer cells with a propensity for bone metastasis express high levels of cadherin-11 and reduced levels of E-cadherin.
TextSentencer_T5 350-529 Sentence denotes Downregulation of cadherin-11 inhibits interaction of prostate cancer cells with osteoblasts in vitro and homing of prostate cancer cells to bone in an animal model of metastasis.
T5 350-529 Sentence denotes Downregulation of cadherin-11 inhibits interaction of prostate cancer cells with osteoblasts in vitro and homing of prostate cancer cells to bone in an animal model of metastasis.
TextSentencer_T6 530-625 Sentence denotes These findings indicate that targeting cadherin-11 may prevent prostate cancer bone metastasis.
T6 530-625 Sentence denotes These findings indicate that targeting cadherin-11 may prevent prostate cancer bone metastasis.
TextSentencer_T7 626-764 Sentence denotes To explore this possibility, a panel of 21 monoclonal antibodies (mAb) was generated against the extracellular (EC) domain of cadherin-11.
T7 626-764 Sentence denotes To explore this possibility, a panel of 21 monoclonal antibodies (mAb) was generated against the extracellular (EC) domain of cadherin-11.
TextSentencer_T8 765-904 Sentence denotes Two antibodies, mAbs 2C7 and 1A5, inhibited cadherin-11-mediated cell-cell aggregation in vitro using L-cells transfected with cadherin-11.
T8 765-904 Sentence denotes Two antibodies, mAbs 2C7 and 1A5, inhibited cadherin-11-mediated cell-cell aggregation in vitro using L-cells transfected with cadherin-11.
TextSentencer_T9 905-1055 Sentence denotes Both antibodies demonstrated specificity to cadherin-11, and neither antibody recognized E-cadherin or N-cadherin on C4-2B or PC3 cells, respectively.
T9 905-1055 Sentence denotes Both antibodies demonstrated specificity to cadherin-11, and neither antibody recognized E-cadherin or N-cadherin on C4-2B or PC3 cells, respectively.
TextSentencer_T10 1056-1189 Sentence denotes Furthermore, mAb 2C7 inhibited cadherin-11-mediated aggregation between the highly metastatic PC3-mm2 cells and MC3T3-E1 osteoblasts.
T10 1056-1189 Sentence denotes Furthermore, mAb 2C7 inhibited cadherin-11-mediated aggregation between the highly metastatic PC3-mm2 cells and MC3T3-E1 osteoblasts.
TextSentencer_T11 1190-1384 Sentence denotes Mechanistically, a series of deletion mutants revealed a unique motif, aa 343-348, in the cadherin-11 EC3 domain that is recognized by mAb 2C7 and that this motif coordinated cell-cell adhesion.
T11 1190-1384 Sentence denotes Mechanistically, a series of deletion mutants revealed a unique motif, aa 343-348, in the cadherin-11 EC3 domain that is recognized by mAb 2C7 and that this motif coordinated cell-cell adhesion.
TextSentencer_T12 1385-1534 Sentence denotes Importantly, administration of mAb 2C7 in a prophylactic setting effectively prevented metastasis of PC3-mm2 cells to bone in an in vivo mouse model.
T12 1385-1534 Sentence denotes Importantly, administration of mAb 2C7 in a prophylactic setting effectively prevented metastasis of PC3-mm2 cells to bone in an in vivo mouse model.
TextSentencer_T13 1535-1691 Sentence denotes These results show that targeting the extracellular domain of cadherin-11 can limit cellular adhesion and metastatic dissemination of prostate cancer cells.
T13 1535-1691 Sentence denotes These results show that targeting the extracellular domain of cadherin-11 can limit cellular adhesion and metastatic dissemination of prostate cancer cells.
TextSentencer_T14 1692-1705 Sentence denotes IMPLICATIONS:
T14 1692-1705 Sentence denotes IMPLICATIONS:
TextSentencer_T15 1706-1806 Sentence denotes Monotherapy using a cadherin-11 antibody is a suitable option for the prevention of bone metastases.
T15 1706-1806 Sentence denotes Monotherapy using a cadherin-11 antibody is a suitable option for the prevention of bone metastases.