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PubMed:23824362 JSONTXT 11 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-94 Sentence denotes Genetic predisposition to radiation induced sarcoma: possible role for BRCA and p53 mutations.
T1 0-94 Sentence denotes Genetic predisposition to radiation induced sarcoma: possible role for BRCA and p53 mutations.
TextSentencer_T2 95-197 Sentence denotes The estimated incidence of radiation-associated sarcoma (RAS) is 0.03-0.2 % in 5 years post treatment.
T2 95-197 Sentence denotes The estimated incidence of radiation-associated sarcoma (RAS) is 0.03-0.2 % in 5 years post treatment.
TextSentencer_T3 198-317 Sentence denotes Most cancer predisposing genes are involved in DNA repair; therefore, elevated RAS risk in these patients is plausible.
T3 198-317 Sentence denotes Most cancer predisposing genes are involved in DNA repair; therefore, elevated RAS risk in these patients is plausible.
TextSentencer_T4 318-411 Sentence denotes Cases of angiosarcoma post breast cancer treatment were reported in BRCA1 and BRCA2 carriers.
T4 318-411 Sentence denotes Cases of angiosarcoma post breast cancer treatment were reported in BRCA1 and BRCA2 carriers.
TextSentencer_T5 412-532 Sentence denotes We report the genetic evaluation of seven cases with suspected RAS from patients counseled in our cancer-genetic clinic.
T5 412-532 Sentence denotes We report the genetic evaluation of seven cases with suspected RAS from patients counseled in our cancer-genetic clinic.
TextSentencer_T6 533-642 Sentence denotes Of 2,885 breast cancer patient, 470 were BRCA1 or two mutation carriers and three were p53 mutation carriers.
T6 533-642 Sentence denotes Of 2,885 breast cancer patient, 470 were BRCA1 or two mutation carriers and three were p53 mutation carriers.
TextSentencer_T7 643-750 Sentence denotes Of them seven developed sarcoma in the field of irradiation; five in the chest wall and two in other sites.
T7 643-750 Sentence denotes Of them seven developed sarcoma in the field of irradiation; five in the chest wall and two in other sites.
TextSentencer_T8 751-869 Sentence denotes Genetic evaluation revealed BRCA1 mutation in two, BRCA2 mutation in additional patient and a carrier of p53 mutation.
T8 751-869 Sentence denotes Genetic evaluation revealed BRCA1 mutation in two, BRCA2 mutation in additional patient and a carrier of p53 mutation.
TextSentencer_T9 870-1043 Sentence denotes The estimation of risk for RAS in patients with genetic predisposition is limited due to the rarity of this event, and the bias in referral to the clinic toward younger age.
T9 870-1043 Sentence denotes The estimation of risk for RAS in patients with genetic predisposition is limited due to the rarity of this event, and the bias in referral to the clinic toward younger age.
TextSentencer_T10 1044-1211 Sentence denotes With these limitations the rate of RAS is 0.43 % (2/470, 95 % CI -0.17 to 1.02, SE = 0.3) in this group in a median follow-up of 8.2 years (range 1 month to 51 years).
T10 1044-1211 Sentence denotes With these limitations the rate of RAS is 0.43 % (2/470, 95 % CI -0.17 to 1.02, SE = 0.3) in this group in a median follow-up of 8.2 years (range 1 month to 51 years).
TextSentencer_T11 1212-1366 Sentence denotes If we assume irradiation for the breast in 80 % of the patients than rate of RAS in group is proximately 0.53 % (2/376, 95 % CI -0.21 to 1.26, SE = 0.37).
T11 1212-1366 Sentence denotes If we assume irradiation for the breast in 80 % of the patients than rate of RAS in group is proximately 0.53 % (2/376, 95 % CI -0.21 to 1.26, SE = 0.37).
TextSentencer_T12 1367-1481 Sentence denotes A BRCA1 carrier which had sarcoma after irradiation to head and neck carcinoma was not included in these analyses.
T12 1367-1481 Sentence denotes A BRCA1 carrier which had sarcoma after irradiation to head and neck carcinoma was not included in these analyses.
TextSentencer_T13 1482-1581 Sentence denotes In conclusion, we found a high frequency of BRCA1/2 mutation among our patients diagnosed with RAS.
T13 1482-1581 Sentence denotes In conclusion, we found a high frequency of BRCA1/2 mutation among our patients diagnosed with RAS.
TextSentencer_T14 1582-1742 Sentence denotes However, we estimated approximately twofold increase in the risk of RAS in BRCA1/2 carriers which was not significant compared to reports in general population.
T14 1582-1742 Sentence denotes However, we estimated approximately twofold increase in the risk of RAS in BRCA1/2 carriers which was not significant compared to reports in general population.
TextSentencer_T15 1743-1917 Sentence denotes Therefore, RAS is a rare event in BRCA carriers as in the general population, and should not be considered in the decision regarding irradiation treatment in this population.
T15 1743-1917 Sentence denotes Therefore, RAS is a rare event in BRCA carriers as in the general population, and should not be considered in the decision regarding irradiation treatment in this population.