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PubMed:23708697 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-131 Sentence denotes ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells.
T1 0-131 Sentence denotes ERK and PI3K signaling cascades induce Nrf2 activation and regulate cell viability partly through Nrf2 in human glioblastoma cells.
TextSentencer_T2 132-298 Sentence denotes The ERK and PI3K signaling cascades are aberrantly activated in human glioblastoma cells, resulting in the dysregulation of numerous downstream transcription factors.
T2 132-298 Sentence denotes The ERK and PI3K signaling cascades are aberrantly activated in human glioblastoma cells, resulting in the dysregulation of numerous downstream transcription factors.
TextSentencer_T3 299-406 Sentence denotes The dark side of the transcription factor, NF-E2-related factor 2 (Nrf2) in human cancer has been revealed.
T3 299-406 Sentence denotes The dark side of the transcription factor, NF-E2-related factor 2 (Nrf2) in human cancer has been revealed.
TextSentencer_T4 407-479 Sentence denotes It has been accepted that high levels of Nrf2 promote tumor progression.
T4 407-479 Sentence denotes It has been accepted that high levels of Nrf2 promote tumor progression.
TextSentencer_T5 480-604 Sentence denotes In the present study, we investigated the effect of the ERK and PI3K signaling cascades on Nrf2 in human glioblastoma cells.
T5 480-604 Sentence denotes In the present study, we investigated the effect of the ERK and PI3K signaling cascades on Nrf2 in human glioblastoma cells.
TextSentencer_T6 605-814 Sentence denotes Immunohistochemical staining for Nrf2 in clinical specimens showed that the expression and nuclear localization of Nrf2 were increased in human glioblastoma tissues when compared to peritumoral normal tissues.
T6 605-814 Sentence denotes Immunohistochemical staining for Nrf2 in clinical specimens showed that the expression and nuclear localization of Nrf2 were increased in human glioblastoma tissues when compared to peritumoral normal tissues.
TextSentencer_T7 815-1061 Sentence denotes In addition, we detected decreased nuclear localization of Nrf2 following combined treatment with ERK and PI3K inhibitors in three human glioblastoma cell lines and selected the cell line (U251) most sensitive to the inhibitors for further study.
T7 815-1061 Sentence denotes In addition, we detected decreased nuclear localization of Nrf2 following combined treatment with ERK and PI3K inhibitors in three human glioblastoma cell lines and selected the cell line (U251) most sensitive to the inhibitors for further study.
TextSentencer_T8 1062-1231 Sentence denotes Our data demonstrated that inhibition of ERK and PI3K not only suppressed the nuclear accumulation of Nrf2 protein but also decreased the expression of the Nrf2 protein.
T8 1062-1231 Sentence denotes Our data demonstrated that inhibition of ERK and PI3K not only suppressed the nuclear accumulation of Nrf2 protein but also decreased the expression of the Nrf2 protein.
TextSentencer_T9 1232-1333 Sentence denotes In addition, combined inhibition of ERK and PI3K also decreased the mRNA levels of Nrf2 target genes.
T9 1232-1333 Sentence denotes In addition, combined inhibition of ERK and PI3K also decreased the mRNA levels of Nrf2 target genes.
TextSentencer_T10 1334-1457 Sentence denotes Finally, we found that Nrf2 overexpression partly reversed the ERK and PI3K inhibitor-induced inhibition of cell viability.
T10 1334-1457 Sentence denotes Finally, we found that Nrf2 overexpression partly reversed the ERK and PI3K inhibitor-induced inhibition of cell viability.
TextSentencer_T11 1458-1632 Sentence denotes Therefore, the ERK and PI3K signaling cascades regulate the expression and activation of Nrf2 and control cell viability partly through Nrf2 in U251 human glioblastoma cells.
T11 1458-1632 Sentence denotes Therefore, the ERK and PI3K signaling cascades regulate the expression and activation of Nrf2 and control cell viability partly through Nrf2 in U251 human glioblastoma cells.
TextSentencer_T12 1633-1763 Sentence denotes Thus, targeting the ERK and PI3K signaling cascades for Nrf2 activation may provide new methods for the treatment of glioblastoma.
T12 1633-1763 Sentence denotes Thus, targeting the ERK and PI3K signaling cascades for Nrf2 activation may provide new methods for the treatment of glioblastoma.