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PubMed:23618899 JSONTXT 9 Projects

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Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-98 Sentence denotes Expression of WWOX and FHIT is downregulated by exposure to arsenite in human uroepithelial cells.
T1 0-98 Sentence denotes Expression of WWOX and FHIT is downregulated by exposure to arsenite in human uroepithelial cells.
TextSentencer_T2 99-325 Sentence denotes Ecological studies in Taiwan, Chile, Argentina, Bangladesh, and Mexico have confirmed significant dose-dependent associations between ingestion of arsenic-contaminated drinking water and the risk of various human malignancies.
T2 99-325 Sentence denotes Ecological studies in Taiwan, Chile, Argentina, Bangladesh, and Mexico have confirmed significant dose-dependent associations between ingestion of arsenic-contaminated drinking water and the risk of various human malignancies.
TextSentencer_T3 326-416 Sentence denotes The FHIT and WWOX genes are active in common fragile sites FRA3B and FRA16D, respectively.
T3 326-416 Sentence denotes The FHIT and WWOX genes are active in common fragile sites FRA3B and FRA16D, respectively.
TextSentencer_T4 417-516 Sentence denotes Reduced expression of FHIT or WWOX is known to be an early indicator of carcinogen-induced cancers.
T4 417-516 Sentence denotes Reduced expression of FHIT or WWOX is known to be an early indicator of carcinogen-induced cancers.
TextSentencer_T5 517-627 Sentence denotes However, the effect of arsenite on the expressions and molecular mechanisms of these markers is still unclear.
T5 517-627 Sentence denotes However, the effect of arsenite on the expressions and molecular mechanisms of these markers is still unclear.
TextSentencer_T6 628-1099 Sentence denotes The aims of this study were (i) to observe the expression of ATR, WWOX and FHIT proteins in urothelial carcinoma (UC) between endemic and non-endemic areas of blackfoot disease (BFD) by immunohistochemical analyses; (ii) to compare expression of these genes between arsenite-treated SV-HUC-1 human epithelial cells and rat uroepithelial cells; and (iii) to determine the role of DNMT and MEK inhibitors on expressions of WWOX and FHIT in response to arsenite in SV-HUC-1.
T6 628-1099 Sentence denotes The aims of this study were (i) to observe the expression of ATR, WWOX and FHIT proteins in urothelial carcinoma (UC) between endemic and non-endemic areas of blackfoot disease (BFD) by immunohistochemical analyses; (ii) to compare expression of these genes between arsenite-treated SV-HUC-1 human epithelial cells and rat uroepithelial cells; and (iii) to determine the role of DNMT and MEK inhibitors on expressions of WWOX and FHIT in response to arsenite in SV-HUC-1.
TextSentencer_T7 1100-1270 Sentence denotes The experiments revealed that expressions of ATR, WWOX and FHIT in UC significantly differed between BFD areas and non-BFD areas (p=0.003, 0.009 and 0.021, respectively).
T7 1100-1270 Sentence denotes The experiments revealed that expressions of ATR, WWOX and FHIT in UC significantly differed between BFD areas and non-BFD areas (p=0.003, 0.009 and 0.021, respectively).
TextSentencer_T8 1271-1397 Sentence denotes In fact, the results for the arsenite-treated groups showed that ATR, WWOX and FHIT are downregulated by arsenite in SV-HUC-1.
T8 1271-1397 Sentence denotes In fact, the results for the arsenite-treated groups showed that ATR, WWOX and FHIT are downregulated by arsenite in SV-HUC-1.
TextSentencer_T9 1398-1503 Sentence denotes However, the inhibitors suppressed the effects of arsenite on WWOX and FHIT proteins and mRNA expression.
T9 1398-1503 Sentence denotes However, the inhibitors suppressed the effects of arsenite on WWOX and FHIT proteins and mRNA expression.
TextSentencer_T10 1504-1612 Sentence denotes In conclusion, arsenite decreased expressions of ATR, WWOX and FHIT via ERK1/2 activation in SV-HUC-1 cells.
T10 1504-1612 Sentence denotes In conclusion, arsenite decreased expressions of ATR, WWOX and FHIT via ERK1/2 activation in SV-HUC-1 cells.
TextSentencer_T11 1613-1723 Sentence denotes These findings confirm that dysregulations of these markers may contribute to arsenite-induced carcinogenesis.
T11 1613-1723 Sentence denotes These findings confirm that dysregulations of these markers may contribute to arsenite-induced carcinogenesis.