| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T1 |
0-175 |
Sentence |
denotes |
Induction of C-X-C chemokine receptor type 7 (CXCR7) switches stromal cell-derived factor-1 (SDF-1) signaling and phagocytic activity in macrophages linked to atherosclerosis. |
| T2 |
176-389 |
Sentence |
denotes |
The discovery of CXCR7 as a new receptor for SDF-1 places many previously described SDF-1 functions attributed to CXCR4 in question, though whether CXCR7 acts as a signaling or "decoy" receptor has been in debate. |
| T3 |
390-546 |
Sentence |
denotes |
It is known that CXCR7 is not expressed in normal blood leukocytes; however, the potential role of leukocyte CXCR7 in disease states has not been addressed. |
| T4 |
547-660 |
Sentence |
denotes |
The aim of this study was to determine the expression and function of macrophage CXCR7 linked to atherosclerosis. |
| T5 |
661-790 |
Sentence |
denotes |
Here, we show that CXCR7 was detected in macrophage-positive area of aortic atheroma of ApoE-null mice, but not in healthy aorta. |
| T6 |
791-938 |
Sentence |
denotes |
During monocyte differentiation to macrophages, CXCR7 was up-regulated at mRNA and protein levels, with more expression in M1 than in M2 phenotype. |
| T7 |
939-1129 |
Sentence |
denotes |
In addition, CXCR7 induction was associated with a SDF-1 signaling switch from the pro-survival ERK and AKT pathways in monocytes to the pro-inflammatory JNK and p38 pathways in macrophages. |
| T8 |
1130-1240 |
Sentence |
denotes |
The latter effect was mimicked by a CXCR7-selective agonist TC14012 and abolished by siRNA knockdown of CXCR7. |
| T9 |
1241-1447 |
Sentence |
denotes |
Furthermore, CXCR7 activation increased macrophage phagocytic activity, which was suppressed by CXCR7 siRNA silencing or by inhibiting either the JNK or p38 pathways, but was not affected by blocking CXCR4. |
| T10 |
1448-1577 |
Sentence |
denotes |
Finally, activation of CXCR7 by I-TAC showed a similar signaling and phagocytic activity in macrophages with no detectable CXCR3. |
| T11 |
1578-1821 |
Sentence |
denotes |
We conclude that CXCR7 is induced during monocyte-to-macrophage differentiation, which is required for SDF-1 and I-TAC signaling to JNK and p38 pathways, leading to enhanced macrophage phagocytosis, thus possibly contributing to atherogenesis. |
