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PubMed:23558898 JSONTXT 10 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-150 Sentence denotes Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma.
T1 0-150 Sentence denotes Tumour-suppressive microRNA-874 contributes to cell proliferation through targeting of histone deacetylase 1 in head and neck squamous cell carcinoma.
TextSentencer_T2 151-162 Sentence denotes BACKGROUND:
T2 151-162 Sentence denotes BACKGROUND:
TextSentencer_T3 163-405 Sentence denotes Our recent studies of microRNA (miRNA) expression signature demonstrated that microRNA-874 (miR-874) was significantly downregulated in maxillary sinus squamous cell carcinoma (MSSCC), and a putative tumour-suppressive miRNA in human cancers.
T3 163-405 Sentence denotes Our recent studies of microRNA (miRNA) expression signature demonstrated that microRNA-874 (miR-874) was significantly downregulated in maxillary sinus squamous cell carcinoma (MSSCC), and a putative tumour-suppressive miRNA in human cancers.
TextSentencer_T4 406-628 Sentence denotes Our aim of this study was to investigate the functional significance of miR-874 in cancer cells and to identify novel miR-874-mediated cancer pathways and responsible genes in head and neck squamous cell carcinoma (HNSCC).
T4 406-628 Sentence denotes Our aim of this study was to investigate the functional significance of miR-874 in cancer cells and to identify novel miR-874-mediated cancer pathways and responsible genes in head and neck squamous cell carcinoma (HNSCC).
TextSentencer_T5 629-637 Sentence denotes METHODS:
T5 629-637 Sentence denotes METHODS:
TextSentencer_T6 638-796 Sentence denotes Gain-of-function studies using mature miR-874 were performed to investigate cell proliferation and cell cycle distribution in HNSCC cell lines (SAS and FaDu).
T6 638-796 Sentence denotes Gain-of-function studies using mature miR-874 were performed to investigate cell proliferation and cell cycle distribution in HNSCC cell lines (SAS and FaDu).
TextSentencer_T7 797-927 Sentence denotes To identify miR-874-mediated molecular pathways and targets, we utilised gene expression analysis and in silico database analysis.
T7 797-927 Sentence denotes To identify miR-874-mediated molecular pathways and targets, we utilised gene expression analysis and in silico database analysis.
TextSentencer_T8 928-1034 Sentence denotes Loss-of-function assays were performed to investigate the functional significance of miR-874 target genes.
T8 928-1034 Sentence denotes Loss-of-function assays were performed to investigate the functional significance of miR-874 target genes.
TextSentencer_T9 1035-1043 Sentence denotes RESULTS:
T9 1035-1043 Sentence denotes RESULTS:
TextSentencer_T10 1044-1214 Sentence denotes Expression levels of miR-874 were significantly downregulated in HNSCC tissues (including oral, pharyngeal and laryngeal SCCs) compared with normal counterpart epithelia.
T10 1044-1214 Sentence denotes Expression levels of miR-874 were significantly downregulated in HNSCC tissues (including oral, pharyngeal and laryngeal SCCs) compared with normal counterpart epithelia.
TextSentencer_T11 1215-1367 Sentence denotes Restoration of miR-874 in SAS and FaDu cell lines revealed significant inhibition of cell proliferation and induction of G2/M arrest and cell apoptosis.
T11 1215-1367 Sentence denotes Restoration of miR-874 in SAS and FaDu cell lines revealed significant inhibition of cell proliferation and induction of G2/M arrest and cell apoptosis.
TextSentencer_T12 1368-1470 Sentence denotes Our expression data and in silico analysis demonstrated that miR-874 modulated the cell cycle pathway.
T12 1368-1470 Sentence denotes Our expression data and in silico analysis demonstrated that miR-874 modulated the cell cycle pathway.
TextSentencer_T13 1471-1556 Sentence denotes Moreover, histone deacetylase 1 (HDAC1) was a candidate target of miR-874 regulation.
T13 1471-1556 Sentence denotes Moreover, histone deacetylase 1 (HDAC1) was a candidate target of miR-874 regulation.
TextSentencer_T14 1557-1629 Sentence denotes Luciferase reporter assays showed that miR-874 directly regulated HDAC1.
T14 1557-1629 Sentence denotes Luciferase reporter assays showed that miR-874 directly regulated HDAC1.
TextSentencer_T15 1630-1757 Sentence denotes Silencing of the HDAC1 gene significantly inhibited cell proliferation and induced G2/M arrest and cell apoptosis in SAS cells.
T15 1630-1757 Sentence denotes Silencing of the HDAC1 gene significantly inhibited cell proliferation and induced G2/M arrest and cell apoptosis in SAS cells.
TextSentencer_T16 1758-1770 Sentence denotes CONCLUSIONS:
T16 1758-1770 Sentence denotes CONCLUSIONS:
TextSentencer_T17 1771-1893 Sentence denotes Downregulation of miR-874 was a frequent event in HNSCC. miR-874 acted as a tumour suppressor and directly targeted HDAC1.
T17 1771-1893 Sentence denotes Downregulation of miR-874 was a frequent event in HNSCC. miR-874 acted as a tumour suppressor and directly targeted HDAC1.
TextSentencer_T18 1894-2090 Sentence denotes Recognition of tumour-suppressive miRNA-mediated cancer pathways provides new insights into the potential mechanisms of HNSCC oncogenesis and suggests novel therapeutic strategies for the disease.
T18 1894-2090 Sentence denotes Recognition of tumour-suppressive miRNA-mediated cancer pathways provides new insights into the potential mechanisms of HNSCC oncogenesis and suggests novel therapeutic strategies for the disease.