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PubMed:23548897 JSONTXT 26 Projects

Annnotations TAB TSV DIC JSON TextAE Lectin_function IAV-Glycan

Id Subject Object Predicate Lexical cue
T1 0-140 Sentence denotes G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.
T2 141-152 Sentence denotes BACKGROUND:
T3 153-223 Sentence denotes Signaling pathways underlying BV8-mediated oncogenesis remain unknown.
T4 224-338 Sentence denotes RESULTS: BV8-STAT3 forms a feed-forward loop in both normal and malignant myeloid cells and promotes tumor growth.
T5 339-444 Sentence denotes CONCLUSION: JAK2/STAT3 signaling plays critical roles in BV8-mediated myeloid cell-dependent oncogenesis.
T6 445-458 Sentence denotes SIGNIFICANCE:
T7 459-588 Sentence denotes This study identifies a novel role of BV8-STAT3 signaling in mediating cross-talk between tumor microenvironment and tumor cells.
T8 589-708 Sentence denotes An important role of BV8 in mobilization of myeloid cells and myeloid cell-dependent angiogenesis has been established.
T9 709-867 Sentence denotes Recently, it has also been shown that granulocyte colony-stimulating factor (G-CSF)-induced BV8 expression is STAT3 dependent in CD11b(+)Gr1(+) myeloid cells.
T10 868-1061 Sentence denotes However, the BV8 downstream signaling pathway(s) intrinsic to myeloid cells crucial for angiogenesis, and potentially also for development of cancers of myeloid origin, remains largely unknown.
T11 1062-1260 Sentence denotes Here we show that BV8 activates STAT3, which is critical for regulating genes important for both tumor cell proliferation/survival and tumor angiogenesis, in both normal and malignant myeloid cells.
T12 1261-1403 Sentence denotes Further, BV8-induced STAT3 activation requires Janus-activated kinase 2 (JAK2) activity as shown by both genetic and pharmacologic inhibition.
T13 1404-1608 Sentence denotes Knocking down BV8 in human myeloid leukemia cells inhibits STAT3 activity and expression of STAT3 downstream angiogenic and pro-proliferation/survival genes, leading to a decrease in tumor cell viability.
T14 1609-1701 Sentence denotes BV8 shRNA expressing leukemia cells exhibit reduced STAT3 activity and tumor growth in vivo.
T15 1702-1919 Sentence denotes Taken together, we have delineated a signaling pathway downstream of BV8 that plays critical roles in both the tumor microenvironment and malignant myeloid cells for angiogenesis and tumor cell proliferation/survival.